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OPKO Health’s Annual Declaration in Compliance with California Health and Safety Codes §§ 119400-119402 (FY 2019)

It is the policy of OPKO to maintain the highest level of professional and ethical standards in the conduct of its business and to comply with all applicable laws in the United States and in all foreign countries where it operates. To ensure compliance with this policy, the company has adopted a formal Compliance Program in accordance with California Health and Safety Codes §§ 119400-119402 (“California’s Healthcare Compliance Program Requirements”), and, to the best of its knowledge and based on its good faith understanding of such statutory requirements, declares that it is in compliance with California’s Healthcare Compliance Program Requirements. While even the best compliance program cannot guarantee that individual unethical employees engage in improper or unethical conduct, we believe that our compliance program has been reasonably designed, implemented and enforced with the goal of preventing and detecting such improper conduct. Furthermore, as required by best compliance practices, we continuously and regularly assesses its effectiveness and implement changes or refinements where needed. This Declaration is effective as of December 31st, 2018 for the January 1, 2019 through December 31, 2019 declaration period. Copies of OPKO’s Code of Conduct and Business Ethics and of its Compliance Program may be obtained by clicking the links below or by contacting OPKO’s Compliance Department at Compliance@opko.com

2018 Code of Ethics