Exhibit 21

SUBSIDIARIES OF OPKO HEALTH, INC.

NAME |  | JURISDICTION OF INCORPORATION
OPKO Pharmaceuticals, LLC |  | Delaware
OPKO Diagnostics, LLC |  | Delaware
ModeX Therapeutics, Inc. |  | Delaware
OPKO Chile, S.A. |  | Chile
Arama Natural Products Distribuidora, Ltda |  | Chile
Pharmacos Exakta S.A. de C.V. |  | Mexico
FineTech Pharmaceutical Ltd |  | Israel
OPKO Health Europe, S.L. |  | Spain
OPKO Biologics, Ltd |  | Israel
OPKO Renal, LLC |  | Canada
Curna, Inc. |  | Delaware
BioReference Health, LLC |  | Delaware
EirGen Pharma Limited |  | Ireland
Transition Therapeutics, Corp. ULC |  | Nova Scotia