Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Schedule of Topic 606 Impact (Details)

v3.10.0.1
Summary of Significant Accounting Policies - Schedule of Topic 606 Impact (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Income Statement [Abstract]                      
Total revenues $ 221,852 $ 249,815 $ 263,685 $ 254,914 $ 160,983 $ 246,040 $ 292,601 $ 266,382 $ 990,266 $ 966,006 $ 1,117,494
Selling, general and administrative                 358,346 414,628 407,331
Research and development                 125,586 126,435 113,871
Statement of Financial Position [Abstract]                      
Other current assets and prepaid expenses 35,052       42,513       35,052 42,513  
Accrued expenses 203,513       225,796       203,513 225,796  
Other long-term liabilities, principally contract liabilities, contingent consideration and lines of credit 198,968       256,415       198,968 256,415  
Accumulated deficit (1,197,078)       (1,048,914)       (1,197,078) (1,048,914)  
Statement of Cash Flows [Abstract]                      
Net loss $ (76,070) $ (27,655) $ (6,201) $ (43,114) (217,914) $ (35,917) $ (16,916) $ (34,503) (153,040) (305,250) (48,359)
Other current assets and prepaid expenses                 2,276 4,771 17,262
Contract liabilities                 (61,264) (58,876) (50,893)
Revenue from services                      
Income Statement [Abstract]                      
Total revenues                 813,248 782,710 928,572
Revenue from transfer of intellectual property and other                      
Income Statement [Abstract]                      
Total revenues                 $ 69,906 75,537 105,455
As originally reported                      
Income Statement [Abstract]                      
Selling, general and administrative                   520,994 490,888
Research and development                   125,186 111,205
Statement of Financial Position [Abstract]                      
Other current assets and prepaid expenses         37,113         37,113  
Accrued expenses         215,102         215,102  
Other long-term liabilities, principally contract liabilities, contingent consideration and lines of credit         219,954         219,954  
Accumulated deficit         (1,007,159)         (1,007,159)  
Statement of Cash Flows [Abstract]                      
Net loss                   (308,870) (25,083)
Other current assets and prepaid expenses                   10,171  
Contract liabilities                   (60,656) (74,169)
As originally reported | Revenue from services                      
Income Statement [Abstract]                      
Total revenues                   889,076 1,012,129
As originally reported | Revenue from transfer of intellectual property and other                      
Income Statement [Abstract]                      
Total revenues                   70,668 126,065
Accounting Standards Update 2014-09 | Effect of change                      
Income Statement [Abstract]                      
Total revenues                   (41,800)  
Selling, general and administrative                   (106,366) (83,557)
Research and development                   1,249 2,666
Statement of Financial Position [Abstract]                      
Other current assets and prepaid expenses         5,400         5,400  
Accrued expenses         10,694         10,694  
Other long-term liabilities, principally contract liabilities, contingent consideration and lines of credit         36,461         36,461  
Accumulated deficit         $ (41,755)         (41,755)  
Statement of Cash Flows [Abstract]                      
Net loss                   3,620 (23,276)
Other current assets and prepaid expenses                   (5,400)  
Contract liabilities                   1,780 23,276
Accounting Standards Update 2014-09 | Effect of change | Revenue from services                      
Income Statement [Abstract]                      
Total revenues                   (106,366) (83,557)
Accounting Standards Update 2014-09 | Effect of change | Revenue from transfer of intellectual property and other                      
Income Statement [Abstract]                      
Total revenues                   $ 4,869 $ (20,610)