Annual report pursuant to Section 13 and 15(d)

Acquisitions, Investments, and Licenses - Narrative (Details)

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Acquisitions, Investments, and Licenses - Narrative (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Business Acquisition [Line Items]      
Total assets of equity method investees $ 234,300,000    
Total liabilities of equity method investees 85,900,000    
Net losses of equity method investees (179,800,000)    
Market value of equity method investees 15,300,000    
Gain (loss) on sale of investments $ (113,000)    
Write down to other assets   $ 8,800,000  
Pharmsynthez      
Business Acquisition [Line Items]      
Ownership percentage 9.00%    
Cocrystal Pharma      
Business Acquisition [Line Items]      
Ownership percentage 9.00%    
NIMS      
Business Acquisition [Line Items]      
Ownership percentage 1.00%    
Neovasc      
Business Acquisition [Line Items]      
Ownership percentage 4.00%    
Warrants to purchase common shares (in shares) 29,000    
InCellDx, Inc      
Business Acquisition [Line Items]      
Ownership percentage 29.00%    
BioCardia, Inc.      
Business Acquisition [Line Items]      
Ownership percentage 5.00%    
Warrants to purchase common shares (in shares) 400,000    
Vested warrants (in shares) 200,000    
Xenetic Biosciences, Inc.      
Business Acquisition [Line Items]      
Ownership percentage 4.00%    
Warrants to purchase common shares (in shares) 500,000    
Phio Pharmaceuticals      
Business Acquisition [Line Items]      
Equity security investments, ownership percentage 0.00%    
Warrants to purchase common shares (in shares) 22,000    
VBI Vaccines Inc      
Business Acquisition [Line Items]      
Equity security investments, ownership percentage 7.00%    
Chromadex Corporation      
Business Acquisition [Line Items]      
Equity security investments, ownership percentage 0.00%    
MabVax      
Business Acquisition [Line Items]      
Equity security investments, ownership percentage 2.00%    
Eloxx Pharmaceuticals      
Business Acquisition [Line Items]      
Equity security investments, ownership percentage 4.00%    
Cocrystal      
Business Acquisition [Line Items]      
Warrants to purchase common shares (in shares) 33,000    
InCellDx Inc.      
Business Acquisition [Line Items]      
Write down of investment $ 2,900,000    
Warrants to purchase common shares (in shares) 700,000    
Zebra      
Business Acquisition [Line Items]      
Ownership percentage 29.00%    
Zebra | Series A Preferred Stock      
Business Acquisition [Line Items]      
Investment owned, shares (in shares) 1,260,000    
Zebra | Restricted Stock      
Business Acquisition [Line Items]      
Investment owned, shares (in shares) 900,000    
Other Income (Expense), Net      
Business Acquisition [Line Items]      
Gain (loss) on sale of investments $ 25,800 $ 1,500,000 $ 0
Variable Interest Entity, Not Primary Beneficiary | Zebra      
Business Acquisition [Line Items]      
Ownership percentage 29.00%