Annual report pursuant to Section 13 and 15(d)

Income Taxes - Narrative (Details)

v3.10.0.1
Income Taxes - Narrative (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Operating Loss Carryforwards [Line Items]        
Approximate amount of federal net operating loss carryforward that may not be utilized $ 53,400      
Total gross unrecognized tax benefit 17,513 $ 21,347 $ 27,545 $ 8,595
Increase in unrecognized tax benefit 8,400      
Decrease in unrecognized tax benefit 4,600      
Unrecognized tax benefits that would impact effective tax rate (14,200) (12,400) $ 6,100  
Income tax interest and penalties (1,900) $ 400    
Approximate unrecognized tax benefits $ 1,300      
Minimum        
Operating Loss Carryforwards [Line Items]        
Tax credit expiration period 15 years      
Maximum        
Operating Loss Carryforwards [Line Items]        
Tax credit expiration period 20 years      
Research and development tax credit carryforwards        
Operating Loss Carryforwards [Line Items]        
Research and development tax credit carryforwards $ 21,700      
Federal        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 606,600      
State        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 801,800      
Foreign        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 152,300      
Foreign | OPKO Biologics        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards $ 86,100