Annual report pursuant to Section 13 and 15(d)

Related Party Transactions - Narrative (Details)

v3.10.0.1
Related Party Transactions - Narrative (Details)
1 Months Ended 12 Months Ended
Nov. 08, 2018
USD ($)
$ / shares
shares
May 31, 2018
shares
Apr. 30, 2018
shares
Feb. 28, 2018
USD ($)
Nov. 30, 2017
USD ($)
shares
Jul. 31, 2017
USD ($)
shares
May 31, 2017
USD ($)
shares
Apr. 30, 2017
USD ($)
shares
Dec. 31, 2016
USD ($)
shares
Aug. 31, 2016
USD ($)
shares
Dec. 31, 2018
USD ($)
shares
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
shares
Jan. 01, 2017
USD ($)
ft²
Nov. 30, 2016
USD ($)
Oct. 31, 2016
shares
Related Party Transaction [Line Items]                                
Private placement agreement number of shares (in shares) 26,500,000                              
Private placement agreement price per share (in dollars per share) | $ / shares $ 3.49                              
Private placement agreement value of shares | $ $ 92,500,000                              
Credit line capacity | $                     $ 197,189,000          
Investments in investees | $                     $ 1,000,000 $ 9,625,000 $ 14,424,000      
Reverse stock split ratio                       0.083        
Zebra                                
Related Party Transaction [Line Items]                                
Investment ownership percentage                     29.00%          
Neovasc                                
Related Party Transaction [Line Items]                                
Investment ownership percentage                     4.00%          
Payments in equity method investment | $         $ 3,000,000.0                      
Warrants to purchase common shares (in shares)                     29,000          
Neovasc | Equity securities                                
Related Party Transaction [Line Items]                                
Equity method shares purchased in period (in shares)         20,547                      
Chromadex Corporation                                
Related Party Transaction [Line Items]                                
Equity security investments, ownership percentage                     0.00%          
MabVax                                
Related Party Transaction [Line Items]                                
Equity security investments, ownership percentage                     2.00%          
Investments in investees | $           $ 100,000 $ 500,000     $ 1,000,000.0            
MabVax | Equity securities                                
Related Party Transaction [Line Items]                                
Warrants to purchase common shares (in shares)                   138,600            
Available-for-sale securities shares purchased in period (in shares)                   69,300            
MabVax | Series G Preferred Stock                                
Related Party Transaction [Line Items]                                
Available-for-sale securities shares purchased in period (in shares)           50,714                    
MabVax | Series L Preferred Stock                                
Related Party Transaction [Line Items]                                
Available-for-sale securities shares purchased in period (in shares)             1,667                  
MabVax | Series I Preferred Stock                                
Related Party Transaction [Line Items]                                
Available-for-sale securities shares purchased in period (in shares)             107,607                  
Cocrystal Pharma                                
Related Party Transaction [Line Items]                                
Investment ownership percentage                     9.00%          
NIMS                                
Related Party Transaction [Line Items]                                
Investment ownership percentage                     1.00%          
BioCardia, Inc.                                
Related Party Transaction [Line Items]                                
Investment ownership percentage                     5.00%          
Warrants to purchase common shares (in shares)                     400,000          
Cocrystal                                
Related Party Transaction [Line Items]                                
Payments in equity method investment | $               $ 1,000,000.0   $ 2,000,000.0            
Warrants to purchase common shares (in shares)                     33,000          
Cocrystal | Equity securities                                
Related Party Transaction [Line Items]                                
Equity method shares purchased in period (in shares)               138,889   162,602            
InCellDx, Inc                                
Related Party Transaction [Line Items]                                
Investment ownership percentage                     29.00%          
BioCardia, Inc. | Equity securities                                
Related Party Transaction [Line Items]                                
Investment owned, shares (in shares)                               418,977
Dr Frost                                
Related Party Transaction [Line Items]                                
Payments in equity method investment | $                 $ 2,500,000              
Dr Frost | Equity securities                                
Related Party Transaction [Line Items]                                
Investment owned, shares (in shares)                 1,602,564       1,602,564      
Dr Frost and Mr Pfenniger | Museum of Science, Inc                                
Related Party Transaction [Line Items]                                
Future contributions to related party | $                             $ 1,000,000.0  
Real Estate Holdings LLC                                
Related Party Transaction [Line Items]                                
Area of real estate property (in square feet) | ft²                           29,500    
Monthly operating lease payment in year one | $                           $ 81,000    
Monthly operating lease payment in year five | $                           $ 86,000    
Reimbursement Of Travel Expense | Dr Frost                                
Related Party Transaction [Line Items]                                
Reimbursement paid to related party for travel | $                     $ 238,000 $ 361,000 $ 298,000      
Series A Warrant | Neovasc                                
Related Party Transaction [Line Items]                                
Warrants to purchase common shares (in shares)         20,547                      
Series B Warrant | Neovasc                                
Related Party Transaction [Line Items]                                
Warrants to purchase common shares (in shares)         20,547                      
Exercise of warrant number of securities received (in shares)     1,069,090                          
Series C Warrant | Neovasc                                
Related Party Transaction [Line Items]                                
Warrants to purchase common shares (in shares)         8,221                      
Convertible Debt | Cocrystal                                
Related Party Transaction [Line Items]                                
Payments in equity method investment | $       $ 1,000,000.0                        
Convertible Debt | Cocrystal | Equity securities                                
Related Party Transaction [Line Items]                                
Convertible debt shares issued (in shares)   538,544                            
Convertible Debt | 5% Convertible Notes                                
Related Party Transaction [Line Items]                                
Interest rate of notes payable       5.00%                        
Debt face amount | $       $ 55,000,000.0                        
Chief Executive Officer                                
Related Party Transaction [Line Items]                                
Private placement agreement value of shares | $ 70,000,000                              
Chief Technical Officer                                
Related Party Transaction [Line Items]                                
Private placement agreement value of shares | $ 2,000,000                              
Line of Credit | Unsecured Debt                                
Related Party Transaction [Line Items]                                
Credit line capacity | $ $ 60,000,000                              
Interest rate of notes payable 10.00%                              
Line of Credit | Unsecured Debt | Dr Frost                                
Related Party Transaction [Line Items]                                
Credit line capacity | $ $ 60,000,000