Annual report pursuant to Section 13 and 15(d)

Segments - Operating Segments (Details)

v3.10.0.1
Segments - Operating Segments (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Segment Reporting Information [Line Items]                      
Total revenues $ 221,852 $ 249,815 $ 263,685 $ 254,914 $ 160,983 $ 246,040 $ 292,601 $ 266,382 $ 990,266 $ 966,006 $ 1,117,494
Operating loss                 (171,197) (276,442) (96,551)
Depreciation and amortization                 97,344 102,093 96,576
Income (loss) from investment in investees                 (14,497) (14,471) (7,652)
Assets 2,451,072       2,589,956       2,451,072 2,589,956  
Goodwill 700,193       717,099       700,193 717,099 704,603
United States                      
Segment Reporting Information [Line Items]                      
Total revenues                 837,509 803,853 933,498
Ireland                      
Segment Reporting Information [Line Items]                      
Total revenues                 78,102 80,905 114,509
Chile                      
Segment Reporting Information [Line Items]                      
Total revenues                 41,216 44,286 35,364
Spain                      
Segment Reporting Information [Line Items]                      
Total revenues                 18,195 18,285 15,812
Israel                      
Segment Reporting Information [Line Items]                      
Total revenues                 9,479 13,951 15,317
Mexico                      
Segment Reporting Information [Line Items]                      
Total revenues                 5,598 4,605 2,988
Other                      
Segment Reporting Information [Line Items]                      
Total revenues                 167 121 6
Corporate, Non-Segment                      
Segment Reporting Information [Line Items]                      
Operating loss                 (43,614) (55,615) (60,040)
Depreciation and amortization                 91 138 89
Income (loss) from investment in investees                 0 0 0
Assets 52,413       66,004       52,413 66,004  
Goodwill 0       0       0 0  
Pharmaceutical | Operating Segments                      
Segment Reporting Information [Line Items]                      
Operating loss                 (82,641) (84,287) (33,117)
Depreciation and amortization                 28,007 27,513 18,254
Income (loss) from investment in investees                 (10,822) (12,646) (7,665)
Assets 1,236,499       1,282,564       1,236,499 1,282,564  
Goodwill 247,407       264,313       247,407 264,313  
Diagnostics | Operating Segments                      
Segment Reporting Information [Line Items]                      
Operating loss                 (44,942) (136,540) (3,394)
Depreciation and amortization                 69,246 74,442 78,233
Income (loss) from investment in investees                 (3,675) (1,825) 13
Assets 1,162,160       1,241,388       1,162,160 1,241,388  
Goodwill $ 452,786       $ 452,786       452,786 452,786  
Revenue from services                      
Segment Reporting Information [Line Items]                      
Total revenues                 813,248 782,710 928,572
Revenue from services | Corporate, Non-Segment                      
Segment Reporting Information [Line Items]                      
Total revenues                 0 0 0
Revenue from services | Pharmaceutical | Operating Segments                      
Segment Reporting Information [Line Items]                      
Total revenues                 0 0 0
Revenue from services | Diagnostics | Operating Segments                      
Segment Reporting Information [Line Items]                      
Total revenues                 813,248 782,710 928,572
Product                      
Segment Reporting Information [Line Items]                      
Total revenues                 107,112 107,759 83,467
Product | Pharmaceutical | Operating Segments                      
Segment Reporting Information [Line Items]                      
Total revenues                 107,112 107,759 83,467
Revenue from transfer of intellectual property and other                      
Segment Reporting Information [Line Items]                      
Total revenues                 69,906 75,537 105,455
Revenue from transfer of intellectual property and other | Corporate, Non-Segment                      
Segment Reporting Information [Line Items]                      
Total revenues                 0 0 0
Revenue from transfer of intellectual property and other | Pharmaceutical | Operating Segments                      
Segment Reporting Information [Line Items]                      
Total revenues                 69,906 75,537 105,455
Revenue from transfer of intellectual property and other | Diagnostics | Operating Segments                      
Segment Reporting Information [Line Items]                      
Total revenues                 $ 0 $ 0 $ 0