Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.19.1
Related Party Transactions (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Feb. 20, 2019
USD ($)
Nov. 08, 2018
USD ($)
$ / shares
shares
Mar. 31, 2019
USD ($)
shares
Feb. 28, 2019
USD ($)
May 31, 2018
shares
Apr. 30, 2018
shares
Feb. 28, 2018
USD ($)
Nov. 30, 2017
USD ($)
shares
Apr. 30, 2017
USD ($)
shares
Nov. 30, 2016
USD ($)
Mar. 31, 2019
USD ($)
shares
Mar. 31, 2018
USD ($)
Dec. 31, 2018
Mar. 01, 2019
shares
Jan. 01, 2017
USD ($)
ft²
Related Party Transaction [Line Items]                              
Private placement agreement number of shares (in shares) | shares   26,500,000                          
Private placement agreement price per share (in dollars per share) | $ / shares   $ 3.49                          
Private placement agreement value of shares   $ 92,500,000                          
Credit line capacity     $ 197,171,000               $ 197,171,000        
Repayments of lines of credit                     $ 35,313,000 $ 12,420,000      
Reverse stock split                         0.01    
Pharmsynthez                              
Related Party Transaction [Line Items]                              
Equity method investment, ownership percentage     9.00%               9.00%        
Zebra                              
Related Party Transaction [Line Items]                              
Equity method investment, ownership percentage     29.00%               29.00%        
Stock ownership percentage                     29.00%        
Neovasc                              
Related Party Transaction [Line Items]                              
Equity method investment, ownership percentage     5.00%               5.00%        
Additional investment in equity method investment               $ 3,000,000.0              
ChromaDex Corporation                              
Related Party Transaction [Line Items]                              
Ownership percentage     0.10%               0.10%        
MabVax                              
Related Party Transaction [Line Items]                              
Ownership percentage     1.00%               1.00%        
COCP                              
Related Party Transaction [Line Items]                              
Equity method investment, ownership percentage     8.00%               8.00%        
Additional investment in equity method investment                 $ 1,000,000.0            
Number of shares into which warrants may be converted (in shares) | shares     33,000               33,000        
NIMS                              
Related Party Transaction [Line Items]                              
Ownership percentage     1.00%               1.00%        
Eloxx Pharmaceuticals                              
Related Party Transaction [Line Items]                              
Ownership percentage     4.00%               4.00%        
BioCardia, Inc.                              
Related Party Transaction [Line Items]                              
Equity method investment, ownership percentage     5.00%               5.00%        
Ownership percentage     5.00%               5.00%        
Number of shares into which warrants may be converted (in shares) | shares     400,000               400,000        
InCellDx, Inc                              
Related Party Transaction [Line Items]                              
Equity method investment, ownership percentage     29.00%               29.00%        
Number of shares into which warrants may be converted (in shares) | shares     700,000               700,000        
Dr. Jan Hsiao                              
Related Party Transaction [Line Items]                              
Private placement agreement value of shares   2,000,000                          
Dr. Frost                              
Related Party Transaction [Line Items]                              
Private placement agreement value of shares   70,000,000                          
Frost Real Estate Holdings LLC                              
Related Party Transaction [Line Items]                              
Area of real estate property (in square feet) | ft²                             29,500
Lease payments per month in first year                             $ 81,000
Lease payments per month in third year                             $ 86,000
Federal Trade Commission Filing Fees | Dr. Jan Hsiao                              
Related Party Transaction [Line Items]                              
Related party transaction amount     $ 125,000                        
Federal Trade Commission Filing Fees | Dr. Frost                              
Related Party Transaction [Line Items]                              
Related party transaction amount       $ 280,000                      
Reimbursement of Travel Expense | Dr. Frost                              
Related Party Transaction [Line Items]                              
Reimbursement paid to related party for travel                     $ 37,000 $ 79,000      
Common Stock | Neovasc                              
Related Party Transaction [Line Items]                              
Equity method investment, additional investment in period (in shares) | shares               20,547              
Common Stock | COCP                              
Related Party Transaction [Line Items]                              
Equity method investment, additional investment in period (in shares) | shares                 138,889            
Xenetic | OPKO Transaction Shares | Affiliate                              
Related Party Transaction [Line Items]                              
Issuance of shares (in shares) | shares                           1,968,750  
Xenetic | Institute Transaction Shares | Affiliate                              
Related Party Transaction [Line Items]                              
Issuance of shares (in shares) | shares                           656,250  
Museum of Science, Inc | Dr Frost and Mr Pfenniger                              
Related Party Transaction [Line Items]                              
Related party future contribution                   $ 1,000,000.0          
Related party future contribution term                   4 years          
Convertible Debt                              
Related Party Transaction [Line Items]                              
Interest rate on credit facility       4.50%                      
Convertible Debt | COCP                              
Related Party Transaction [Line Items]                              
Additional investment in equity method investment             $ 1,000,000.0                
Convertible Debt | Common Stock | COCP                              
Related Party Transaction [Line Items]                              
Shares received after conversion (in shares) | shares         538,544                    
5% Convertible Notes | Convertible Debt                              
Related Party Transaction [Line Items]                              
Interest rate on credit facility             5.00%                
Debt face amount             $ 55,000,000.0                
Series A Warrant | Neovasc                              
Related Party Transaction [Line Items]                              
Number of shares into which warrants may be converted (in shares) | shares               20,547              
Proceeds from warrant exercises                     $ 1,200,000        
Series B Warrant | Neovasc                              
Related Party Transaction [Line Items]                              
Number of shares into which warrants may be converted (in shares) | shares               20,547              
Shares received upon exercise of warrant (in shares) | shares           1,069,090                  
Series C Warrant | Neovasc                              
Related Party Transaction [Line Items]                              
Number of shares into which warrants may be converted (in shares) | shares               8,221              
Shares received upon exercise of warrant (in shares) | shares                     2,266,023        
Line of Credit | Unsecured Debt                              
Related Party Transaction [Line Items]                              
Credit line capacity   $ 60,000,000                          
Interest rate on credit facility   10.00%                          
Line of Credit | Unsecured Debt | Dr. Frost                              
Related Party Transaction [Line Items]                              
Repayments of lines of credit $ 28,800,000