Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement (Form S-8 No.
333-144040) pertaining to the OPKO Health, Inc. 2007 Equity Incentive Plan of our reports dated
March 17, 2010, with respect to the consolidated financial statements and the effectiveness of
internal control over financial reporting of OPKO Health, Inc. in this Annual Report (Form
10-K) for the year ended December 31, 2009.
/s/ Ernst & Young LLP
Certified Public Accountants
March 17, 2010