Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement (Form S-8 No.
333-144040) pertaining to the OPKO Health, Inc. 2007 Equity Incentive Plan of our report dated
March 17, 2010, except for the effects of the restatement described in Note 21, as to which the date is November 10, 2010, with respect to the
consolidated financial statements of OPKO Health, Inc. and subsidiaries, and our report dated March
17, 2010, except for the effects of the material weakness described in the seventh paragraph of
such report, as to which the date is November 10, 2010 with respect to the effectiveness of internal
control over financial reporting of OPKO Health, Inc. and subsidiaries, in this Annual Report (Form
10-K/A) for the year ended December 31, 2009.
/s/ Ernst & Young LLP
Certified Public Accountants
November 10, 2010