Exhibit 31.2
I, Rao Uppaluri, certify that:
  (1)   I have reviewed this Annual Report on Form 10-K/A of OPKO Health, Inc.;
  (2)   Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
Date: February 3, 2011  /s/ Rao Uppaluri    
  Rao Uppaluri   
  Chief Financial Officer