Annual report pursuant to Section 13 and 15(d)

Income Taxes - Narrative (Details)

v3.8.0.1
Income Taxes - Narrative (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating Loss Carryforwards [Line Items]        
Increase in deferred tax asset valuation allowance $ 82,400      
Adoption of ASU 2016-09   $ 31,665    
Approximate amount of federal net operating loss carryforward that may not be utilized 53,400      
Total gross unrecognized tax benefit 21,347 27,545 $ 8,595 $ 5,890
Increase in unrecognized tax benefit 0      
Decrease in unrecognized tax benefit 4,500      
Unrecognized tax benefits that would impact effective tax rate (12,400) 6,100 $ 700  
Income tax interest and penalties 400 100    
Approximate unrecognized tax benefits $ 4,600      
Minimum        
Operating Loss Carryforwards [Line Items]        
Tax credit expiration period 15 years      
Maximum        
Operating Loss Carryforwards [Line Items]        
Tax credit expiration period 20 years      
Research and development tax credit carryforwards        
Operating Loss Carryforwards [Line Items]        
Research and development tax credit carryforwards $ 20,000      
Federal        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 488,700      
State        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 602,900      
Foreign        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 146,900      
Foreign | OPKO Biologics        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards $ 95,800      
Accumulated Deficit        
Operating Loss Carryforwards [Line Items]        
Adoption of ASU 2016-09   $ 31,665