Annual report pursuant to Section 13 and 15(d)

Related Party Transactions - Narrative (Details)

v3.8.0.1
Related Party Transactions - Narrative (Details)
1 Months Ended 12 Months Ended
Nov. 30, 2017
USD ($)
shares
Sep. 30, 2017
shares
Aug. 31, 2017
shares
Jul. 31, 2017
USD ($)
shares
Jun. 30, 2017
USD ($)
shares
May 31, 2017
USD ($)
shares
Apr. 30, 2017
USD ($)
shares
Dec. 31, 2016
USD ($)
shares
Aug. 31, 2016
USD ($)
shares
Jan. 31, 2016
USD ($)
shares
Dec. 31, 2017
USD ($)
shares
Dec. 31, 2016
USD ($)
shares
Dec. 31, 2015
USD ($)
Feb. 28, 2017
USD ($)
Jan. 01, 2017
USD ($)
ft²
Nov. 30, 2016
USD ($)
Oct. 31, 2016
shares
Related Party Transaction [Line Items]                                  
Investment ownership percentage                     4.00%            
Reverse stock split ratio                     0.0833            
Eloxx Pharmaceuticals                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investments, ownership percentage                     5.00%            
Amount invested | $         $ 1,500,000                        
Eloxx Pharmaceuticals | Series C Preferred Stock                                  
Related Party Transaction [Line Items]                                  
Shares purchased in period (in shares)         99,915                        
Zebra                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage                     29.00%            
Sevion                                  
Related Party Transaction [Line Items]                                  
Payments in equity method investment | $       $ 1,500,000                          
Equity method shares purchased in period (in shares)       10,000,000                          
Neovasc                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage                     5.00%            
Payments in equity method investment | $ $ 3,000,000                                
Warrants to purchase common shares (in shares)                     4,900,000            
Neovasc | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Equity method shares purchased in period (in shares) 2,054,794                                
Chromadex Corporation                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investments, ownership percentage                     1.00%            
MabVax                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investments, ownership percentage                     2.00%            
Payment for investment in common shares | $       $ 100,000   $ 500,000     $ 1,000,000                
MabVax | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Warrants to purchase common shares (in shares)                 415,800                
Available-for-sale securities shares purchased in period (in shares)                 207,900                
MabVax | Series G Preferred Stock                                  
Related Party Transaction [Line Items]                                  
Available-for-sale securities shares purchased in period (in shares)       152,143   285,714                      
MabVax | Series I Preferred Stock                                  
Related Party Transaction [Line Items]                                  
Available-for-sale securities shares purchased in period (in shares)           322,820                      
Cocrystal                                  
Related Party Transaction [Line Items]                                  
Payments in equity method investment | $             $ 1,000,000   $ 2,000,000                
Warrants to purchase common shares (in shares)                     1,000,000            
Cocrystal | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Equity method shares purchased in period (in shares)             4,166,667   4,878,050                
ARNO                                  
Related Party Transaction [Line Items]                                  
Payment for investment in common shares | $                 $ 300,000 $ 300,000              
ARNO | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Warrants to purchase common shares (in shares)                 357,142                
Available-for-sale securities shares purchased in period (in shares)                 714,285 714,285              
BioCardia, Inc.                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage                     5.00%            
Warrants to purchase common shares (in shares)                     400,000            
Cocrystal Pharma                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage                     9.00%            
NIMS                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage                     1.00%            
Dr Frost and Mr Pfenniger | Museum of Science, Inc                                  
Related Party Transaction [Line Items]                                  
Future contributions to related party | $                               $ 1,000,000  
Sevion                                  
Related Party Transaction [Line Items]                                  
Debt face amount | $                           $ 300,000.0   $ 200,000.0  
Shares converted into (in shares)     4,100,000                            
Sevion | Series C Preferred Stock                                  
Related Party Transaction [Line Items]                                  
Number of shares converted (in shares)   66,667                              
Sevion | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Shares issued after conversion (in shares)   1,250,006                              
Dr Frost                                  
Related Party Transaction [Line Items]                                  
Payment for investment in common shares | $               $ 2,500,000                  
Dr Frost | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Investment owned, shares (in shares)               1,602,564       1,602,564          
BioCardia, Inc. | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Investment owned, shares (in shares)                                 418,977
Real Estate Holdings LLC                                  
Related Party Transaction [Line Items]                                  
Area of real estate property (in square feet) | ft²                             29,500    
Monthly operating lease payment in year one | $                             $ 81,000    
Monthly operating lease payment in year five | $                             $ 86,000    
Reimbursement Of Travel Expense | Dr Frost                                  
Related Party Transaction [Line Items]                                  
Reimbursement paid to related party for travel | $                     $ 361,000 $ 298,000 $ 595,000        
InCellDx, Inc                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage                     29.00%            
Series A Warrant | Neovasc                                  
Related Party Transaction [Line Items]                                  
Warrants to purchase common shares (in shares) 2,054,794                                
Series B Warrant | Neovasc                                  
Related Party Transaction [Line Items]                                  
Warrants to purchase common shares (in shares) 2,054,794                                
Series C Warrant | Neovasc                                  
Related Party Transaction [Line Items]                                  
Warrants to purchase common shares (in shares) 822,192