Annual report pursuant to Section 13 and 15(d)

Acquisitions, Investments, and Licenses - Warrants and Options (Details)

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Acquisitions, Investments, and Licenses - Warrants and Options (Details) - shares
Dec. 31, 2016
Oct. 31, 2015
Jul. 31, 2015
Neovasc      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 1,000,000    
BioCardia, Inc.      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 5,000,000    
Cocrystal      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 1,000,000    
ARNO      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 2,300,000    
Sevion      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 300,000   333,333
MabVax      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 700,000 170,454  
InCellDx Inc.      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 700,000    
Xenetic Biosciences, Inc.      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 500,000    
RXi      
Investment [Line Items]      
Warrants to purchase common shares (in shares) 200,000