Annual report pursuant to Section 13 and 15(d)

Shareholders' Equity (Details Textual)

v2.4.1.9
Shareholders' Equity (Details Textual) (USD $)
12 Months Ended 0 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Mar. 08, 2013
Class of Stock [Line Items]        
Common Stock, shares authorized (in shares) 750,000,000us-gaap_CommonStockSharesAuthorized 750,000,000us-gaap_CommonStockSharesAuthorized    
Common Stock, par value $ 0.01us-gaap_CommonStockParOrStatedValuePerShare $ 0.01us-gaap_CommonStockParOrStatedValuePerShare    
Preferred Stock, shares authorized (in shares) 10,000,000us-gaap_PreferredStockSharesAuthorized      
Preferred Stock, par value (in dollars per share) $ 0.01us-gaap_PreferredStockParOrStatedValuePerShare      
Shares surrendered in lieu of cash payment 426opk_NumberOfSharesSurrenderedInLieuOfCashPayments      
Designate shares of preferred stock 10,000,000opk_ConvertiblePreferredStockSharesDesignatedMaximum      
Payments of Ordinary Dividends, Preferred Stock and Preference Stock $ 0us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock $ 3,015,000us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock $ 0us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock  
Common stock investments, available for sale        
Class of Stock [Line Items]        
Exercise of common stock warrants, shares 3,064,317opk_ExerciseOfCommonStockWarrantsShares
/ us-gaap_StatementClassOfStockAxis
= us-gaap_CommonStockMember
     
Conversion of Stock, Shares Issued       11,290,320us-gaap_ConversionOfStockSharesIssued1
/ us-gaap_StatementClassOfStockAxis
= us-gaap_CommonStockMember
Series A Preferred Stock        
Class of Stock [Line Items]        
Preferred Stock, shares authorized (in shares) 4,000,000us-gaap_PreferredStockSharesAuthorized
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesAPreferredStockMember
     
Preferred stock, shares issued 0us-gaap_PreferredStockSharesIssued
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesAPreferredStockMember
0us-gaap_PreferredStockSharesIssued
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesAPreferredStockMember
   
Preferred stock, shares outstanding 0us-gaap_PreferredStockSharesOutstanding
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesAPreferredStockMember
0us-gaap_PreferredStockSharesOutstanding
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesAPreferredStockMember
   
Series C Preferred Stock        
Class of Stock [Line Items]        
Preferred Stock, shares authorized (in shares) 500,000us-gaap_PreferredStockSharesAuthorized
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesCPreferredStockMember
     
Preferred stock, shares issued 0us-gaap_PreferredStockSharesIssued
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesCPreferredStockMember
0us-gaap_PreferredStockSharesIssued
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesCPreferredStockMember
   
Preferred stock, shares outstanding 0us-gaap_PreferredStockSharesOutstanding
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesCPreferredStockMember
0us-gaap_PreferredStockSharesOutstanding
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesCPreferredStockMember
   
Series D Preferred Stock        
Class of Stock [Line Items]        
Preferred Stock, shares authorized (in shares) 2,000,000us-gaap_PreferredStockSharesAuthorized
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
     
Preferred stock, shares issued 0us-gaap_PreferredStockSharesIssued
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
0us-gaap_PreferredStockSharesIssued
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
   
Preferred stock, shares outstanding 0us-gaap_PreferredStockSharesOutstanding
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
0us-gaap_PreferredStockSharesOutstanding
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
  0us-gaap_PreferredStockSharesOutstanding
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
Rate of dividend per annum 8.00%us-gaap_PreferredStockDividendRatePercentage
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
     
Payments of Ordinary Dividends, Preferred Stock and Preference Stock       3,000,000us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
Number of Series D Preferred Stock converted       1,129,032us-gaap_ConversionOfStockSharesConverted1
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
Total cash dividend     3,000,000us-gaap_DividendsCash
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
 
Preferred Share Per share Arrears     $ 2.30us-gaap_PreferredStockPerShareAmountsOfPreferredDividendsInArrears
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember
 
Preferred Stock, Amount of Preferred Dividends in Arrears     $ 2,600,000us-gaap_PreferredStockAmountOfPreferredDividendsInArrears
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesDPreferredStockMember