Annual report pursuant to Section 13 and 15(d)

Equity-Based Compensation (Details Textual)

v2.4.1.9
Equity-Based Compensation (Details Textual) (USD $)
12 Months Ended
Dec. 31, 2014
Plan
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2009
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of equity-based incentive compensation plans 5opk_NumberOfEquityBasedIncentiveCompensationPlans      
Expiration period 10 years      
Vesting period 5 years     5 years
Excess tax benefits $ 0opk_ShareBasedCompensationExcessTaxBenefits $ 0opk_ShareBasedCompensationExcessTaxBenefits $ 0opk_ShareBasedCompensationExcessTaxBenefits  
Unrecognized compensation cost 41,500,000us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized      
Weighted-average expected period for recognition 3 years 0 months 0 days      
Expected volatility for options based on historical volatility 7 years      
Expected volatility for options based on a peer group 8 years      
Common stock shares reserved for issuance 16,736,892us-gaap_CommonStockCapitalSharesReservedForFutureIssuance      
Intrinsic value of stock options exercised 14,600,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue 59,500,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue 2,400,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue  
Weighted average grant date fair value of stock options granted $ 4.64us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue $ 4.00us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue $ 2.44us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue  
Fair value of stock options vested 10,900,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1 5,900,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1 3,400,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1  
Restricted common stock shares issued       30,000opk_RestrictedStockSharesIssuedDuringPeriod
Selling, General and Administrative Expenses        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Equity based compensation expense 9,700,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_SellingGeneralAndAdministrativeExpensesMember
7,300,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_SellingGeneralAndAdministrativeExpensesMember
3,100,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_SellingGeneralAndAdministrativeExpensesMember
 
Research and Development Expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Equity based compensation expense 5,000,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
3,600,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
2,000,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
 
Cost of Revenue        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Equity based compensation expense 100,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_CostOfSalesMember
     
2007 Equity Incentive Plan        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expiration period       7 years
Continuing Operations        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Equity based compensation expense $ 14,800,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_StatementOperatingActivitiesSegmentAxis
= us-gaap_SegmentContinuingOperationsMember
$ 11,000,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_StatementOperatingActivitiesSegmentAxis
= us-gaap_SegmentContinuingOperationsMember
$ 5,100,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_StatementOperatingActivitiesSegmentAxis
= us-gaap_SegmentContinuingOperationsMember
 
Minimum | 2007 Equity Incentive Plan        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expiration period 7 years      
Maximum | 2007 Equity Incentive Plan        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expiration period 10 years