Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details Textual)

v2.4.1.9
Income Taxes (Details Textual) (USD $)
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Operating Loss Carryforwards [Line Items]        
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost, Unrecognized $ 16,400,000opk_DeferredTaxAssetsTaxDeferredExpenseCompensationandBenefitsSharebasedCompensationCostUnrecognized      
Federal net operating loss carryforwards, utilized 37,200,000us-gaap_UnrecognizedTaxBenefitsResultingInNetOperatingLossCarryforward      
Reversal of uncertain tax benefits 3,190,000us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities        
Income Taxes (Textual) [Abstract]        
Total gross unrecognized tax benefit 5,890,000us-gaap_UnrecognizedTaxBenefits 9,231,000us-gaap_UnrecognizedTaxBenefits 9,245,000us-gaap_UnrecognizedTaxBenefits 5,250,000us-gaap_UnrecognizedTaxBenefits
Increase in unrecognized tax benefit 700,000us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions      
Decrease in unrecognized tax benefit 4,100,000opk_UnrecognizedTaxBenefitsReductionResultingfromLapseofApplicableStatuteofLimitationsandSettlementswithTaxingAuthorities      
Effective income tax rate 900,000us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate      
Accrued interest and penalties on unrecognized tax benefits   200,000us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued    
Approximate unrecognized tax benefits 900,000us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleAmountOfUnrecordedBenefit      
Minimum        
Operating Loss Carryforwards [Line Items]        
Expiration Period 15 years      
Maximum        
Operating Loss Carryforwards [Line Items]        
Expiration Period 20 years      
Research and Development Tax Credit Carryforwards        
Operating Loss Carryforwards [Line Items]        
Research and development tax credit carryforwards 6,100,000us-gaap_TaxCreditCarryforwardAmount
/ us-gaap_TaxCreditCarryforwardAxis
= us-gaap_ResearchMember
     
Federal        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 294,900,000us-gaap_OperatingLossCarryforwards
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_DomesticCountryMember
     
State        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 262,600,000us-gaap_OperatingLossCarryforwards
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_StateAndLocalJurisdictionMember
     
Foreign        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 97,100,000us-gaap_OperatingLossCarryforwards
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_ForeignCountryMember
     
Reversal of uncertain tax benefits 3,200,000us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_ForeignCountryMember
     
Foreign | OPKO Biologics        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards $ 74,000,000us-gaap_OperatingLossCarryforwards
/ us-gaap_BusinessAcquisitionAxis
= opk_OPKOBiologicsMember
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_ForeignCountryMember