Annual report pursuant to Section 13 and 15(d)

Income Taxes - Narrative (Details)

v3.6.0.2
Income Taxes - Narrative (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating Loss Carryforwards [Line Items]        
Increase in equity when deferred tax assets are realized $ 33,700      
Approximate amount of federal net operating loss carryforward that may not be utilized 53,400      
Income Taxes (Textual) [Abstract]        
Total gross unrecognized tax benefit 27,545 $ 8,595 $ 5,890 $ 9,231
Increase in unrecognized tax benefit 19,900      
Decrease in unrecognized tax benefit 300      
Unrecognized tax benefits that would impact effective tax rate 6,100 700 $ 900  
Income tax interest and penalties 100 $ 300    
Approximate unrecognized tax benefits 4,100      
Undistributed earnings of foreign subsidiaries $ 31,200      
Minimum        
Operating Loss Carryforwards [Line Items]        
Tax credit expiration period 15 years      
Maximum        
Operating Loss Carryforwards [Line Items]        
Tax credit expiration period 20 years      
Research and development tax credit carryforwards        
Operating Loss Carryforwards [Line Items]        
Research and development tax credit carryforwards $ 18,500      
Federal        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 409,300      
State        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 406,600      
Foreign        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 186,600      
Foreign | OPKO Biologics        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards $ 98,600