Annual report pursuant to Section 13 and 15(d)

Related Party Transactions - Narrative (Details)

v3.6.0.2
Related Party Transactions - Narrative (Details)
$ / shares in Units, ft² in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2016
USD ($)
shares
Sep. 30, 2016
USD ($)
shares
Aug. 31, 2016
USD ($)
$ / shares
shares
Jan. 31, 2016
USD ($)
shares
Nov. 30, 2015
USD ($)
shares
Oct. 31, 2015
USD ($)
$ / shares
shares
Jul. 31, 2015
USD ($)
shares
Dec. 31, 2016
USD ($)
shares
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Nov. 30, 2016
USD ($)
Oct. 31, 2016
shares
Aug. 31, 2015
$ / shares
May 31, 2015
$ / shares
May 28, 2015
USD ($)
ft²
Common stock investments, available for sale                              
Related Party Transaction [Line Items]                              
Stock price (in dollars per share) | $ / shares     $ 9.10                   $ 12.38 $ 13.88  
Zebra                              
Related Party Transaction [Line Items]                              
Investment ownership percentage 28.00%             28.00%              
Zebra | Series A-2 Preferred Stock                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares)         420,000                    
Sevion                              
Related Party Transaction [Line Items]                              
Investment ownership percentage 3.00%             3.00%              
Warrants to purchase common shares (in shares) 300,000           333,333 300,000              
Sevion | Series C Preferred Stock                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares)             66,667                
Sevion | Common stock investments, available for sale                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares)             666,667                
Neovasc                              
Related Party Transaction [Line Items]                              
Investment ownership percentage 4.00%             4.00%              
Warrants to purchase common shares (in shares) 1,000,000             1,000,000              
Chromadex Corporation                              
Related Party Transaction [Line Items]                              
Available-for-sale investments, ownership percentage 2.00%             2.00%              
MabVax                              
Related Party Transaction [Line Items]                              
Available-for-sale investments, ownership percentage 4.00%             4.00%              
Investment owned, shares (in shares)           340,909                  
Warrants to purchase common shares (in shares) 700,000         170,454   700,000              
Payment for investment in common shares | $     $ 1,000,000     $ 400,000                  
Stock price (in dollars per share) | $ / shares           $ 1.10                  
MabVax | Common stock investments, available for sale                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares)     207,900                        
Warrants to purchase common shares (in shares)     415,800                        
Cocrystal                              
Related Party Transaction [Line Items]                              
Warrants to purchase common shares (in shares) 1,000,000             1,000,000              
Payment for investment in common shares | $   $ 2,000,000                          
Cocrystal | Common stock investments, available for sale                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares)   4,878,050                          
ARNO                              
Related Party Transaction [Line Items]                              
Available-for-sale investments, ownership percentage 5.00%             5.00%              
Warrants to purchase common shares (in shares) 2,300,000             2,300,000              
Payment for investment in common shares | $     $ 300,000 $ 300,000                      
ARNO | Common stock investments, available for sale                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares)     714,285 714,285                      
Warrants to purchase common shares (in shares)     357,142                        
BioCardia, Inc.                              
Related Party Transaction [Line Items]                              
Available-for-sale investments, ownership percentage 5.00%             5.00%              
Warrants to purchase common shares (in shares) 5,000,000             5,000,000              
Cocrystal Pharma                              
Related Party Transaction [Line Items]                              
Investment ownership percentage 8.00%             8.00%              
NIMS                              
Related Party Transaction [Line Items]                              
Available-for-sale investments, ownership percentage 1.00%             1.00%              
Dr Frost and Mr Pfenniger | Museum of Science, Inc                              
Related Party Transaction [Line Items]                              
Future contributions to related party | $                     $ 1,000,000        
Sevion                              
Related Party Transaction [Line Items]                              
Debt face amount | $                     $ 150,000        
Dr Frost                              
Related Party Transaction [Line Items]                              
Payment for investment in common shares | $ $ 2,500,000                            
Dr Frost | Common stock investments, available for sale                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares) 19,230,769             19,230,769              
BioCardia, Inc. | Common stock investments, available for sale                              
Related Party Transaction [Line Items]                              
Investment owned, shares (in shares)                       5,027,726      
Real Estate Holdings LLC                              
Related Party Transaction [Line Items]                              
Area of real estate property (in square feet) | ft²                             25
Monthly operating lease payment in year one | $                             $ 66,000
Monthly operating lease payment in year five | $                             75,000
Tenant improvements for rent reduction | $                             $ 200,000
Equity Method Investee | Zebra                              
Related Party Transaction [Line Items]                              
Payments in equity method investment | $         $ 1,000,000                    
Equity Method Investee | Sevion                              
Related Party Transaction [Line Items]                              
Private placement financing | $             $ 500,000                
Reimbursement Of Travel Expense | Dr Frost                              
Related Party Transaction [Line Items]                              
Reimbursement paid to related party for travel | $               $ 298,000 $ 595,000 $ 175,000          
InCellDx, Inc                              
Related Party Transaction [Line Items]                              
Investment ownership percentage 27.00%             27.00%