Exhibit 31.3
I, Phillip Frost, certify that:
  (1)   I have reviewed this Quarterly Report on Form 10-Q of OPKO Health, Inc.;
  (2)   Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
Date: July 5, 2011  /s/ Phillip Frost    
  Phillip Frost, M.D.   
  Chief Executive Officer