Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.7.0.1
Related Party Transactions (Details)
1 Months Ended 3 Months Ended
Dec. 31, 2016
USD ($)
shares
Sep. 30, 2016
USD ($)
shares
Aug. 31, 2016
USD ($)
shares
Jan. 31, 2016
USD ($)
shares
Mar. 31, 2017
USD ($)
shares
Mar. 31, 2016
USD ($)
Feb. 28, 2017
USD ($)
Jan. 01, 2017
USD ($)
ft²
Nov. 30, 2016
USD ($)
Oct. 31, 2016
shares
Zebra                    
Related Party Transaction [Line Items]                    
Stock ownership percentage         28.00%          
Equity method investment, ownership percentage         29.00%          
Sevion                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage         3.00%          
Number of shares into which warrants may be converted (in shares)         300,000          
Neovasc                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage         4.00%          
Number of shares into which warrants may be converted (in shares)         1,000,000          
ChromaDex Corporation                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage         2.00%          
MabVax                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage         4.00%          
Available-for-sale investment, additional investment in period | $     $ 1,000,000              
Number of shares into which warrants may be converted (in shares)         700,000          
COCP                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage         8.00%          
Available-for-sale investment, additional investment in period | $   $ 2,000,000                
Number of shares into which warrants may be converted (in shares)         1,000,000          
ARNO                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage         0.00%          
Available-for-sale investment, additional investment in period | $     $ 300,000 $ 300,000            
Number of shares into which warrants may be converted (in shares)         2,300,000          
InCellDx, Inc                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage         27.00%          
Number of shares into which warrants may be converted (in shares)         700,000          
BioCardia, Inc.                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage         5.00%          
Available-for-sale investment, ownership percentage         5.00%          
Number of shares into which warrants may be converted (in shares)         5,000,000          
NIMS                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage         1.00%          
Frost Real Estate Holdings LLC                    
Related Party Transaction [Line Items]                    
Area of real estate property (in square feet) | ft²               29,500    
Lease payments per month in first year | $               $ 81,000    
Lease payments per month in third year | $               $ 86,000    
Dr Frost                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, additional investment in period | $ $ 2,500,000                  
Sevion                    
Related Party Transaction [Line Items]                    
Debt face amount | $             $ 300,000.0   $ 200,000.0  
Interest rate on related party loan             6.00%      
Reimbursement Of Travel Expense | Dr Frost                    
Related Party Transaction [Line Items]                    
Reimbursement paid to related party for travel | $         $ 20,000 $ 58,000        
Common Stock | MabVax                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, additional investment in period (in shares)     207,900              
Number of shares into which warrants may be converted (in shares)     415,800              
Common Stock | COCP                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, additional investment in period (in shares)   4,878,050                
Common Stock | ARNO                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, additional investment in period (in shares)     714,285 714,285            
Number of shares into which warrants may be converted (in shares)     357,142              
Common Stock | BioCardia, Inc.                    
Related Party Transaction [Line Items]                    
Investment owned (in shares)                   5,027,726
Common Stock | Dr Frost                    
Related Party Transaction [Line Items]                    
Investment owned (in shares) 19,230,769                  
Museum of Science, Inc | Dr Frost and Mr Pfenniger                    
Related Party Transaction [Line Items]                    
Related party future contribution | $                 $ 1,000,000