Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.4.0.3
Related Party Transactions (Details)
$ / shares in Units, ft² in Thousands, $ in Thousands
1 Months Ended 3 Months Ended
Nov. 30, 2015
USD ($)
shares
Oct. 31, 2015
USD ($)
$ / shares
shares
Jul. 31, 2015
USD ($)
shares
Mar. 31, 2016
USD ($)
shares
Mar. 31, 2015
USD ($)
Jan. 31, 2016
shares
Aug. 31, 2015
$ / shares
May. 31, 2015
$ / shares
May. 28, 2015
USD ($)
ft²
May. 05, 2015
$ / shares
Zebra                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       29.00%            
Additional investment | $ $ 1,000                  
Sevion                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       3.00%            
Invested in common shares | $     $ 500              
Warrants to purchase common shares     333,333 500,000            
Neovasc                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       4.00%            
Warrants to purchase common shares       1,000,000            
MabVax                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage       1.00%            
Invested in common shares | $   $ 400                
Investment owned, shares   340,909                
Warrants to purchase common shares   170,454   1,800,000            
Stock price per share | $ / shares   $ 1.10                
COCP                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       8.00%            
Warrants to purchase common shares       1,000,000            
ARNO                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage       4.00%            
Warrants to purchase common shares       800,000            
Additional investment | $ $ 300                  
InCellDx, Inc                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       27.00%            
Warrants to purchase common shares       700,000            
Equity Method Investee | Zebra                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       29.00%            
Equity Method Investee | Sevion                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       3.00%            
Equity Method Investee | Neovasc                    
Related Party Transaction [Line Items]                    
Equity method investment, ownership percentage       4.00%            
Investee | ChromaDex Corporation                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage       2.00%            
Investee | MabVax                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage       1.00%            
Investee | ARNO                    
Related Party Transaction [Line Items]                    
Available-for-sale investment, ownership percentage       4.00%            
Frost Real Estate Holdings LLC                    
Related Party Transaction [Line Items]                    
Area of real estate property (in square feet) | ft²                 25  
Lease payments per month in first year | $                 $ 66  
Lease payments per month in fifth year | $                 75  
Rent reduction | $                 $ 200  
Reimbursement Of Travel Expense | Dr Frost                    
Related Party Transaction [Line Items]                    
Reimbursement paid to related party for travel | $       $ 58 $ 126          
Series C Preferred Stock | Sevion                    
Related Party Transaction [Line Items]                    
Investment owned, shares     66,667              
Common Stock                    
Related Party Transaction [Line Items]                    
Stock price per share | $ / shares             $ 12.38 $ 13.88   $ 13.88
Common Stock | Sevion                    
Related Party Transaction [Line Items]                    
Investment owned, shares     666,667              
Common Stock | ARNO                    
Related Party Transaction [Line Items]                    
Investment owned, shares           714,285        
Series A-2 Preferred Stock | Zebra                    
Related Party Transaction [Line Items]                    
Investment owned, shares 420,000