Joint Statement of OPKO Health, Inc. and Phillip Frost, Chairman and Chief Executive Officer

Dr. Frost informed the Company that he admitted himself into the hospital within the last few days after experiencing chest pains. Dr. Frost has undergone a successful surgery, and he is expected to make a full recovery. Dr. Frost has been in regular contact with Company management and members of the Board of Directors during his hospitalization, and the Company is continuing to operate normally. The Company will provide further details as appropriate. In the meantime, the OPKO family wishes Dr. Frost a speedy recovery.