Name:

Frost Gamma Investments Trust

Address:

4400 Biscayne Blvd Miami, FL 33137

Designated Filer:

Phillip Frost, M.D.

Issuer Name and Ticker Symbol:

OPKO Health, Inc. (OPK)

Date of Earliest Transaction:

September 29, 2008

Relationship to Issuer:

10% Owner

   

   

  

  

  

FROST GAMMA INVESTMENTS TRUST
/s/ Phillip Frost MD, as trustee
Phillip Frost, M.D., Trustee