(1)

I have reviewed this Annual Report on Form 10-K/A of OPKO Health, Inc.; and

(2)

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

/s/Phillip Frost, M.D.

Chief Executive Officer