NAME

JURISDICTION OF INCORPORATION

OPKO Pharmaceuticals, LLC

Delaware

OPKO Diagnostics, LLC

Delaware

ModeX Therapeutics, Inc.

Delaware

OPKO Chile, S.A.

Chile

Arama Natural Products Distribuidora, Ltda

Chile

Pharmacos Exakta S.A. de C.V.

Mexico

FineTech Pharmaceutical Ltd

Israel

OPKO Health Europe, S.L.

Spain

OPKO Biologics, Ltd

Israel

OPKO Renal, LLC

Canada

Curna, Inc.

Delaware

BioReference Health, LLC

Delaware

EirGen Pharma Limited

Ireland

Transition Therapeutics, Corp. ULC

Nova Scotia