Chair
Member
Audit Committee Position

Richard C. Pfenniger, Jr.

Mr. Pfenniger has served as a director of OPKO since January 2008. Mr. Pfenniger served as CEO and President for Continucare Corporation, a provider of primary care physician and practice management services, and as Chairman of the Board of Directors of Continucare Corporation until 2011. Mr. Pfenniger has also served as the CEO and Vice Chairman of Whitman Education Group, Inc.

Prior to joining Whitman, he served as the Chief Operating Officer of IVAX and as the Senior Vice President-Legal Affairs and General Counsel of IVAX. Mr. Pfenniger currently serves as a director of GP Strategies Corporation, a corporate education and training company, TransEnterix Inc., a medical device company pioneering the use of robotics, IntegraMed America, and BioCardia, Inc., a clinical-stage regenerative medicine company. He also serves as the Vice Chairman of the Board of Trustees and as a member of the Executive Committee of the Phillip and Patricia Frost Museum of Science.

Chair

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

Member

John A. Paganelli

Mr. Paganelli has served as a director of OPKO since December 2003. Previously, Mr. Paganelli served as OPKO's Interim CEO and secretary, and Chairman of OPKO's Board of Directors until 2007. Mr. Paganelli also served as President and CEO of Transamerica Life Insurance Company of New York.

Since 1987, Mr. Paganelli has been a partner in RFG Associates, a financial planning organization. Mr. Paganelli is also the Managing Partner of Pharos Systems Partners, LLC, an investment company, and served as Chairman of the Board of Pharos Systems International, a software company, from 2001 until March 2021. He was Vice President and Executive Vice President of PEG Capital Management, an investment advisory organization. Mr. Paganelli was also an officer and director-stockholder of Mike Barnard Chevrolet, Inc., an automobile dealership. Mr. Paganelli also serves as a director of Western New York Energy, LLC. Mr. Paganelli previously served on the Board of Trustees of Paul Smith's College and the Board of Managers of Bridge Financial Services, LLC.

Member

Audit Committee Charter

Download
Compensation Committee Position

Richard A. Lerner, M.D.

Dr. Lerner served as a director of OPKO from March 2007 until his passing in December 2021. The Board of Directors and staff of OPKO express their gratitude for Dr. Lerner’s many contributions to OPKO and to the advancement of science. Dr. Lerner served as President of The Scripps Research Institute, a leading biomedical research organization based in La Jolla, Calif., from 1986 until 2012, and most recently served as Institute Professor and as a member of its Skaggs Institute for Chemical Biology.

Dr. Lerner received his undergraduate degree from Northwestern University and his M.D. from Stanford Medical School. He was a postdoctoral fellow at Scripps Clinic and Research Foundation, the predecessor of the institute he would eventually lead and help build. During the 1970s he conducted research at the Wister Institute in Philadelphia, then returned to La Jolla where, in 1982, he was appointed chairman of the Department of Molecular Biology. Five years later he assumed the directorship and became its first president in 1991. Under his leadership, The Scripps Research Institute increased laboratory space threefold and more than quadrupled staff levels, placing it among the world’s largest nonprofit biomedical research organizations. In 2006 he oversaw the establishment of the satellite research campus Scripps Florida, in Palm Beach County.

Dr. Lerner is perhaps best known for his research into catalytic antibodies and his extensive studies into protein structure. He has dozens of patents to his name and published more than 400 scientific papers. He has received more than 30 honors and prizes including the Parke-Davis Award in 1978, the San Marino Prize in 1990 and the Wolf Prize in Chemistry in 1994. Dr. Lerner was awarded the California Scientist of the Year Award in 1996 and the University of California Presidential Medal in 2002. He was elected to the Royal Swedish Academy of Sciences and the U.S. National Academy of Sciences, and was a co-recipient of the 2012 Prince of Asturias award, considered the Spanish Nobel Prize.

Chair

Robert S. Fishel, M.D.

Dr. Fishel, an eminent cardiologist, serves as a director of several private companies. He is a director and founder of Florida Electrophysiology Associates and has been the CEO and President since 1997, a director and senior managing partner of Renaissance Properties since 1989, a director and founding partner of Catalyst Development Partners since 2009; a director and President of ALSAR Ltd Partnership since 1996, and a director and founder of NewPace Medical and its Chief Medical Officer since 2012. Dr. Fishel is an Affiliate Associate Professor of Medicine at the Charles E. Schmidt College of Medicine, Florida Atlantic University School of Medicine's Division of Integrated Sciences.

Member

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

Member

Compensation Committee Charter

Download
Corporate Governance and Nominating Committee Position

John A. Paganelli

Mr. Paganelli has served as a director of OPKO since December 2003. Previously, Mr. Paganelli served as OPKO's Interim CEO and secretary, and Chairman of OPKO's Board of Directors until 2007. Mr. Paganelli also served as President and CEO of Transamerica Life Insurance Company of New York.

Since 1987, Mr. Paganelli has been a partner in RFG Associates, a financial planning organization. Mr. Paganelli is also the Managing Partner of Pharos Systems Partners, LLC, an investment company, and served as Chairman of the Board of Pharos Systems International, a software company, from 2001 until March 2021. He was Vice President and Executive Vice President of PEG Capital Management, an investment advisory organization. Mr. Paganelli was also an officer and director-stockholder of Mike Barnard Chevrolet, Inc., an automobile dealership. Mr. Paganelli also serves as a director of Western New York Energy, LLC. Mr. Paganelli previously served on the Board of Trustees of Paul Smith's College and the Board of Managers of Bridge Financial Services, LLC.

Chair

Richard A. Lerner, M.D.

Dr. Lerner served as a director of OPKO from March 2007 until his passing in December 2021. The Board of Directors and staff of OPKO express their gratitude for Dr. Lerner’s many contributions to OPKO and to the advancement of science. Dr. Lerner served as President of The Scripps Research Institute, a leading biomedical research organization based in La Jolla, Calif., from 1986 until 2012, and most recently served as Institute Professor and as a member of its Skaggs Institute for Chemical Biology.

Dr. Lerner received his undergraduate degree from Northwestern University and his M.D. from Stanford Medical School. He was a postdoctoral fellow at Scripps Clinic and Research Foundation, the predecessor of the institute he would eventually lead and help build. During the 1970s he conducted research at the Wister Institute in Philadelphia, then returned to La Jolla where, in 1982, he was appointed chairman of the Department of Molecular Biology. Five years later he assumed the directorship and became its first president in 1991. Under his leadership, The Scripps Research Institute increased laboratory space threefold and more than quadrupled staff levels, placing it among the world’s largest nonprofit biomedical research organizations. In 2006 he oversaw the establishment of the satellite research campus Scripps Florida, in Palm Beach County.

Dr. Lerner is perhaps best known for his research into catalytic antibodies and his extensive studies into protein structure. He has dozens of patents to his name and published more than 400 scientific papers. He has received more than 30 honors and prizes including the Parke-Davis Award in 1978, the San Marino Prize in 1990 and the Wolf Prize in Chemistry in 1994. Dr. Lerner was awarded the California Scientist of the Year Award in 1996 and the University of California Presidential Medal in 2002. He was elected to the Royal Swedish Academy of Sciences and the U.S. National Academy of Sciences, and was a co-recipient of the 2012 Prince of Asturias award, considered the Spanish Nobel Prize.

Member

Corporate Governance and Nominating Committee Charter

Download
Independent Investment Committee Position

Robert S. Fishel, M.D.

Dr. Fishel, an eminent cardiologist, serves as a director of several private companies. He is a director and founder of Florida Electrophysiology Associates and has been the CEO and President since 1997, a director and senior managing partner of Renaissance Properties since 1989, a director and founding partner of Catalyst Development Partners since 2009; a director and President of ALSAR Ltd Partnership since 1996, and a director and founder of NewPace Medical and its Chief Medical Officer since 2012. Dr. Fishel is an Affiliate Associate Professor of Medicine at the Charles E. Schmidt College of Medicine, Florida Atlantic University School of Medicine's Division of Integrated Sciences.

Chair

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

Member

John A. Paganelli

Mr. Paganelli has served as a director of OPKO since December 2003. Previously, Mr. Paganelli served as OPKO's Interim CEO and secretary, and Chairman of OPKO's Board of Directors until 2007. Mr. Paganelli also served as President and CEO of Transamerica Life Insurance Company of New York.

Since 1987, Mr. Paganelli has been a partner in RFG Associates, a financial planning organization. Mr. Paganelli is also the Managing Partner of Pharos Systems Partners, LLC, an investment company, and served as Chairman of the Board of Pharos Systems International, a software company, from 2001 until March 2021. He was Vice President and Executive Vice President of PEG Capital Management, an investment advisory organization. Mr. Paganelli was also an officer and director-stockholder of Mike Barnard Chevrolet, Inc., an automobile dealership. Mr. Paganelli also serves as a director of Western New York Energy, LLC. Mr. Paganelli previously served on the Board of Trustees of Paul Smith's College and the Board of Managers of Bridge Financial Services, LLC.

Member

Independent Investment Committee Charter

Download
Succession Committee Position

Robert S. Fishel, M.D.

Dr. Fishel, an eminent cardiologist, serves as a director of several private companies. He is a director and founder of Florida Electrophysiology Associates and has been the CEO and President since 1997, a director and senior managing partner of Renaissance Properties since 1989, a director and founding partner of Catalyst Development Partners since 2009; a director and President of ALSAR Ltd Partnership since 1996, and a director and founder of NewPace Medical and its Chief Medical Officer since 2012. Dr. Fishel is an Affiliate Associate Professor of Medicine at the Charles E. Schmidt College of Medicine, Florida Atlantic University School of Medicine's Division of Integrated Sciences.

Member

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

Member

Richard A. Lerner, M.D.

Dr. Lerner has served as a director of OPKO since March 2007. Previously, from 1986 until 2011, Dr. Lerner previously served as President of The Scripps Research Institute, a private, non-profit biomedical research organization, and is currently serving as an institute professor. Dr. Lerner is a member of numerous scientific associations, including the National Academy of Science and the Royal Swedish Academy of Sciences. He previously served as a director of Kraft Foods, Inc., Xencor, a privately-held biotechnology company, Teva Pharmaceuticals Industries, Ltd., Sequenom, Inc., a life sciences company, and on the Siemens' Advisory Board for Molecular Medicine of Siemens AG.

Dr. Lerner also currently serves as director of Intra-Cellular Therapies, a privately-held biotechnology company, and Zebra Biologics, Inc., a privately-held pre-clinical stage biopharmaceutical company,

Member

Richard C. Pfenniger, Jr.

Mr. Pfenniger has served as a director of OPKO since January 2008. Mr. Pfenniger served as CEO and President for Continucare Corporation, a provider of primary care physician and practice management services, and as Chairman of the Board of Directors of Continucare Corporation until 2011. Mr. Pfenniger has also served as the CEO and Vice Chairman of Whitman Education Group, Inc.

Prior to joining Whitman, he served as the Chief Operating Officer of IVAX and as the Senior Vice President-Legal Affairs and General Counsel of IVAX. Mr. Pfenniger currently serves as a director of GP Strategies Corporation, a corporate education and training company, TransEnterix Inc., a medical device company pioneering the use of robotics, IntegraMed America, and BioCardia, Inc., a clinical-stage regenerative medicine company. He also serves as the Vice Chairman of the Board of Trustees and as a member of the Executive Committee of the Phillip and Patricia Frost Museum of Science.

Member

Succession Committee Charter

Download

Richard C. Pfenniger, Jr.

Mr. Pfenniger has served as a director of OPKO since January 2008. Mr. Pfenniger served as CEO and President for Continucare Corporation, a provider of primary care physician and practice management services, and as Chairman of the Board of Directors of Continucare Corporation until 2011. Mr. Pfenniger has also served as the CEO and Vice Chairman of Whitman Education Group, Inc.

Prior to joining Whitman, he served as the Chief Operating Officer of IVAX and as the Senior Vice President-Legal Affairs and General Counsel of IVAX. Mr. Pfenniger currently serves as a director of GP Strategies Corporation, a corporate education and training company, TransEnterix Inc., a medical device company pioneering the use of robotics, IntegraMed America, and BioCardia, Inc., a clinical-stage regenerative medicine company. He also serves as the Vice Chairman of the Board of Trustees and as a member of the Executive Committee of the Phillip and Patricia Frost Museum of Science.

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

John A. Paganelli

Mr. Paganelli has served as a director of OPKO since December 2003. Previously, Mr. Paganelli served as OPKO's Interim CEO and secretary, and Chairman of OPKO's Board of Directors until 2007. Mr. Paganelli also served as President and CEO of Transamerica Life Insurance Company of New York.

Since 1987, Mr. Paganelli has been a partner in RFG Associates, a financial planning organization. Mr. Paganelli is also the Managing Partner of Pharos Systems Partners, LLC, an investment company, and served as Chairman of the Board of Pharos Systems International, a software company, from 2001 until March 2021. He was Vice President and Executive Vice President of PEG Capital Management, an investment advisory organization. Mr. Paganelli was also an officer and director-stockholder of Mike Barnard Chevrolet, Inc., an automobile dealership. Mr. Paganelli also serves as a director of Western New York Energy, LLC. Mr. Paganelli previously served on the Board of Trustees of Paul Smith's College and the Board of Managers of Bridge Financial Services, LLC.

Richard A. Lerner, M.D.

Dr. Lerner served as a director of OPKO from March 2007 until his passing in December 2021. The Board of Directors and staff of OPKO express their gratitude for Dr. Lerner’s many contributions to OPKO and to the advancement of science. Dr. Lerner served as President of The Scripps Research Institute, a leading biomedical research organization based in La Jolla, Calif., from 1986 until 2012, and most recently served as Institute Professor and as a member of its Skaggs Institute for Chemical Biology.

Dr. Lerner received his undergraduate degree from Northwestern University and his M.D. from Stanford Medical School. He was a postdoctoral fellow at Scripps Clinic and Research Foundation, the predecessor of the institute he would eventually lead and help build. During the 1970s he conducted research at the Wister Institute in Philadelphia, then returned to La Jolla where, in 1982, he was appointed chairman of the Department of Molecular Biology. Five years later he assumed the directorship and became its first president in 1991. Under his leadership, The Scripps Research Institute increased laboratory space threefold and more than quadrupled staff levels, placing it among the world’s largest nonprofit biomedical research organizations. In 2006 he oversaw the establishment of the satellite research campus Scripps Florida, in Palm Beach County.

Dr. Lerner is perhaps best known for his research into catalytic antibodies and his extensive studies into protein structure. He has dozens of patents to his name and published more than 400 scientific papers. He has received more than 30 honors and prizes including the Parke-Davis Award in 1978, the San Marino Prize in 1990 and the Wolf Prize in Chemistry in 1994. Dr. Lerner was awarded the California Scientist of the Year Award in 1996 and the University of California Presidential Medal in 2002. He was elected to the Royal Swedish Academy of Sciences and the U.S. National Academy of Sciences, and was a co-recipient of the 2012 Prince of Asturias award, considered the Spanish Nobel Prize.

Robert S. Fishel, M.D.

Dr. Fishel, an eminent cardiologist, serves as a director of several private companies. He is a director and founder of Florida Electrophysiology Associates and has been the CEO and President since 1997, a director and senior managing partner of Renaissance Properties since 1989, a director and founding partner of Catalyst Development Partners since 2009; a director and President of ALSAR Ltd Partnership since 1996, and a director and founder of NewPace Medical and its Chief Medical Officer since 2012. Dr. Fishel is an Affiliate Associate Professor of Medicine at the Charles E. Schmidt College of Medicine, Florida Atlantic University School of Medicine's Division of Integrated Sciences.

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

John A. Paganelli

Mr. Paganelli has served as a director of OPKO since December 2003. Previously, Mr. Paganelli served as OPKO's Interim CEO and secretary, and Chairman of OPKO's Board of Directors until 2007. Mr. Paganelli also served as President and CEO of Transamerica Life Insurance Company of New York.

Since 1987, Mr. Paganelli has been a partner in RFG Associates, a financial planning organization. Mr. Paganelli is also the Managing Partner of Pharos Systems Partners, LLC, an investment company, and served as Chairman of the Board of Pharos Systems International, a software company, from 2001 until March 2021. He was Vice President and Executive Vice President of PEG Capital Management, an investment advisory organization. Mr. Paganelli was also an officer and director-stockholder of Mike Barnard Chevrolet, Inc., an automobile dealership. Mr. Paganelli also serves as a director of Western New York Energy, LLC. Mr. Paganelli previously served on the Board of Trustees of Paul Smith's College and the Board of Managers of Bridge Financial Services, LLC.

Richard A. Lerner, M.D.

Dr. Lerner served as a director of OPKO from March 2007 until his passing in December 2021. The Board of Directors and staff of OPKO express their gratitude for Dr. Lerner’s many contributions to OPKO and to the advancement of science. Dr. Lerner served as President of The Scripps Research Institute, a leading biomedical research organization based in La Jolla, Calif., from 1986 until 2012, and most recently served as Institute Professor and as a member of its Skaggs Institute for Chemical Biology.

Dr. Lerner received his undergraduate degree from Northwestern University and his M.D. from Stanford Medical School. He was a postdoctoral fellow at Scripps Clinic and Research Foundation, the predecessor of the institute he would eventually lead and help build. During the 1970s he conducted research at the Wister Institute in Philadelphia, then returned to La Jolla where, in 1982, he was appointed chairman of the Department of Molecular Biology. Five years later he assumed the directorship and became its first president in 1991. Under his leadership, The Scripps Research Institute increased laboratory space threefold and more than quadrupled staff levels, placing it among the world’s largest nonprofit biomedical research organizations. In 2006 he oversaw the establishment of the satellite research campus Scripps Florida, in Palm Beach County.

Dr. Lerner is perhaps best known for his research into catalytic antibodies and his extensive studies into protein structure. He has dozens of patents to his name and published more than 400 scientific papers. He has received more than 30 honors and prizes including the Parke-Davis Award in 1978, the San Marino Prize in 1990 and the Wolf Prize in Chemistry in 1994. Dr. Lerner was awarded the California Scientist of the Year Award in 1996 and the University of California Presidential Medal in 2002. He was elected to the Royal Swedish Academy of Sciences and the U.S. National Academy of Sciences, and was a co-recipient of the 2012 Prince of Asturias award, considered the Spanish Nobel Prize.

Robert S. Fishel, M.D.

Dr. Fishel, an eminent cardiologist, serves as a director of several private companies. He is a director and founder of Florida Electrophysiology Associates and has been the CEO and President since 1997, a director and senior managing partner of Renaissance Properties since 1989, a director and founding partner of Catalyst Development Partners since 2009; a director and President of ALSAR Ltd Partnership since 1996, and a director and founder of NewPace Medical and its Chief Medical Officer since 2012. Dr. Fishel is an Affiliate Associate Professor of Medicine at the Charles E. Schmidt College of Medicine, Florida Atlantic University School of Medicine's Division of Integrated Sciences.

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

John A. Paganelli

Mr. Paganelli has served as a director of OPKO since December 2003. Previously, Mr. Paganelli served as OPKO's Interim CEO and secretary, and Chairman of OPKO's Board of Directors until 2007. Mr. Paganelli also served as President and CEO of Transamerica Life Insurance Company of New York.

Since 1987, Mr. Paganelli has been a partner in RFG Associates, a financial planning organization. Mr. Paganelli is also the Managing Partner of Pharos Systems Partners, LLC, an investment company, and served as Chairman of the Board of Pharos Systems International, a software company, from 2001 until March 2021. He was Vice President and Executive Vice President of PEG Capital Management, an investment advisory organization. Mr. Paganelli was also an officer and director-stockholder of Mike Barnard Chevrolet, Inc., an automobile dealership. Mr. Paganelli also serves as a director of Western New York Energy, LLC. Mr. Paganelli previously served on the Board of Trustees of Paul Smith's College and the Board of Managers of Bridge Financial Services, LLC.

Robert S. Fishel, M.D.

Dr. Fishel, an eminent cardiologist, serves as a director of several private companies. He is a director and founder of Florida Electrophysiology Associates and has been the CEO and President since 1997, a director and senior managing partner of Renaissance Properties since 1989, a director and founding partner of Catalyst Development Partners since 2009; a director and President of ALSAR Ltd Partnership since 1996, and a director and founder of NewPace Medical and its Chief Medical Officer since 2012. Dr. Fishel is an Affiliate Associate Professor of Medicine at the Charles E. Schmidt College of Medicine, Florida Atlantic University School of Medicine's Division of Integrated Sciences.

Richard M. Krasno, Ph.D.

Dr. Krasno was appointed to the OPKO Board in 2017. Previously, Dr. Krasno served as executive director of the William R. Kenan, Jr. Charitable Trust and as President of the four affiliated William R. Kenan, Jr. Funds.

Prior to joining the Trust, Dr. Krasno was the President of the Monterey Institute of International Studies in Monterey, California. Dr. Krasno also served as a director of the University of North Carolina Health Care System and as chairman of the board of directors until 2012. He has also served as President and Chief Executive Officer of the Institute of International Education in New York, and as Deputy Assistant Secretary of Education in Washington, D.C.

Dr. Krasno currently serves as a director of Ladenburg Thalmann and BioCardia, Inc. and previously served as a director of Castle Brands, Inc. Dr. Krasno holds a Bachelor of Science from the University of Illinois and a Ph.D. from Stanford University.

Richard A. Lerner, M.D.

Dr. Lerner has served as a director of OPKO since March 2007. Previously, from 1986 until 2011, Dr. Lerner previously served as President of The Scripps Research Institute, a private, non-profit biomedical research organization, and is currently serving as an institute professor. Dr. Lerner is a member of numerous scientific associations, including the National Academy of Science and the Royal Swedish Academy of Sciences. He previously served as a director of Kraft Foods, Inc., Xencor, a privately-held biotechnology company, Teva Pharmaceuticals Industries, Ltd., Sequenom, Inc., a life sciences company, and on the Siemens' Advisory Board for Molecular Medicine of Siemens AG.

Dr. Lerner also currently serves as director of Intra-Cellular Therapies, a privately-held biotechnology company, and Zebra Biologics, Inc., a privately-held pre-clinical stage biopharmaceutical company,

Richard C. Pfenniger, Jr.

Mr. Pfenniger has served as a director of OPKO since January 2008. Mr. Pfenniger served as CEO and President for Continucare Corporation, a provider of primary care physician and practice management services, and as Chairman of the Board of Directors of Continucare Corporation until 2011. Mr. Pfenniger has also served as the CEO and Vice Chairman of Whitman Education Group, Inc.

Prior to joining Whitman, he served as the Chief Operating Officer of IVAX and as the Senior Vice President-Legal Affairs and General Counsel of IVAX. Mr. Pfenniger currently serves as a director of GP Strategies Corporation, a corporate education and training company, TransEnterix Inc., a medical device company pioneering the use of robotics, IntegraMed America, and BioCardia, Inc., a clinical-stage regenerative medicine company. He also serves as the Vice Chairman of the Board of Trustees and as a member of the Executive Committee of the Phillip and Patricia Frost Museum of Science.