Quarterly report pursuant to Section 13 or 15(d)

Acquisitions, Investments and Licenses - Available for Sale Investments, Sale of Investments and Warrants and Options Narrative (Details)

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Acquisitions, Investments and Licenses - Available for Sale Investments, Sale of Investments and Warrants and Options Narrative (Details) - USD ($)
$ in Thousands, shares in Millions
9 Months Ended
Sep. 30, 2016
Dec. 31, 2015
Investment [Line Items]    
Available-for-sale investments $ 5,767 $ 3,615
Rxi Pharmaceuticals Corporation    
Investment [Line Items]    
Ownership percentage 3.00%  
Other-than-temporary impairment charge $ 400  
Available-for-sale investments $ 400  
ChromaDex    
Investment [Line Items]    
Ownership percentage 2.00%  
MabVax    
Investment [Line Items]    
Ownership percentage 4.00%  
Number of shares into which warrants may be converted (in shares) 0.7  
ARNO    
Investment [Line Items]    
Ownership percentage 5.00%  
Number of shares into which warrants may be converted (in shares) 2.2  
Xenetic Biosciences, Inc.    
Investment [Line Items]    
Ownership percentage 3.00%  
Other-than-temporary impairment charge $ 3,500  
Available-for-sale investments $ 1,400  
Neovasc    
Investment [Line Items]    
Number of shares into which warrants may be converted (in shares) 0.1  
Cocrystal    
Investment [Line Items]    
Number of shares into which warrants may be converted (in shares) 1.0  
Sevion    
Investment [Line Items]    
Number of shares into which warrants may be converted (in shares) 0.5  
InCellDx, Inc    
Investment [Line Items]    
Number of shares into which warrants may be converted (in shares) 0.7