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Acquisitions, Investments and Licenses - Available for Sale Investments, Sale of Investments and Warrants and Options Narrative (Details)

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Acquisitions, Investments and Licenses - Available for Sale Investments, Sale of Investments and Warrants and Options Narrative (Details)
shares in Thousands
Jun. 30, 2018
shares
Rxi Pharmaceuticals Corporation  
Investment [Line Items]  
Ownership percentage 1.00%
ChromaDex  
Investment [Line Items]  
Ownership percentage 0.00%
MabVax  
Investment [Line Items]  
Ownership percentage 2.00%
Eloxx Pharmaceuticals  
Investment [Line Items]  
Ownership percentage 4.00%
Xenetic Biosciences, Inc.  
Investment [Line Items]  
Number of shares into which warrants may be converted (in shares) 500
Neovasc  
Investment [Line Items]  
Number of shares into which warrants may be converted (in shares) 2,900
BioCardia, Inc.  
Investment [Line Items]  
Ownership percentage 5.00%
Number of shares into which warrants may be converted (in shares) 400
Investment options, vested (in shares) 100
Cocrystal  
Investment [Line Items]  
Number of shares into which warrants may be converted (in shares) 33
InCellDx, Inc  
Investment [Line Items]  
Number of shares into which warrants may be converted (in shares) 700
Rxi  
Investment [Line Items]  
Number of shares into which warrants may be converted (in shares) 22