Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.19.3
Related Party Transactions (Details)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Feb. 20, 2019
USD ($)
Nov. 08, 2018
USD ($)
$ / shares
shares
Mar. 31, 2019
USD ($)
Feb. 28, 2019
USD ($)
May 31, 2018
shares
Apr. 30, 2018
shares
Feb. 28, 2018
USD ($)
Nov. 30, 2017
USD ($)
shares
Apr. 30, 2017
USD ($)
shares
Nov. 30, 2016
USD ($)
Sep. 30, 2019
USD ($)
shares
Mar. 31, 2019
USD ($)
shares
Sep. 30, 2018
USD ($)
Sep. 30, 2019
USD ($)
shares
Sep. 30, 2018
USD ($)
Dec. 31, 2018
Mar. 01, 2019
shares
Aug. 01, 2017
USD ($)
ft²
Related Party Transaction [Line Items]                                    
Private placement agreement number of shares (in shares) | shares   26,500,000                                
Private placement agreement price per share (in dollars per share) | $ / shares   $ 3.49                                
Private placement agreement value of shares   $ 92,500,000                                
Credit line capacity                     $ 122,435,000     $ 122,435,000        
Repayments of lines of credit                           $ 158,477,000 $ 28,435,000      
Reverse stock split                               0.01    
Reimbursement paid to related party for travel                         $ 34,000   $ 174,000      
Pharmsynthez                                    
Related Party Transaction [Line Items]                                    
Equity method investment, ownership percentage                     9.00%     9.00%        
Zebra                                    
Related Party Transaction [Line Items]                                    
Equity method investment, ownership percentage                     29.00%     29.00%        
Stock ownership percentage                           29.00%        
Neovasc                                    
Related Party Transaction [Line Items]                                    
Equity method investment, ownership percentage                     4.00%     4.00%        
Additional investment in equity method investment               $ 3,000,000.0                    
ChromaDex Corporation                                    
Related Party Transaction [Line Items]                                    
Ownership percentage                     0.10%     0.10%        
MabVax                                    
Related Party Transaction [Line Items]                                    
Ownership percentage                     1.00%     1.00%        
COCP                                    
Related Party Transaction [Line Items]                                    
Equity method investment, ownership percentage                     8.00%     8.00%        
Additional investment in equity method investment                 $ 1,000,000.0                  
Number of shares into which warrants may be converted (in shares) | shares                     33,000     33,000        
NIMS                                    
Related Party Transaction [Line Items]                                    
Ownership percentage                     1.00%     1.00%        
Eloxx Pharmaceuticals                                    
Related Party Transaction [Line Items]                                    
Ownership percentage                     3.00%     3.00%        
BioCardia, Inc.                                    
Related Party Transaction [Line Items]                                    
Equity method investment, ownership percentage                     5.00%     5.00%        
Ownership percentage                     5.00%     5.00%        
Number of shares into which warrants may be converted (in shares) | shares                     47,000     47,000        
InCellDx, Inc                                    
Related Party Transaction [Line Items]                                    
Equity method investment, ownership percentage                     29.00%     29.00%        
Number of shares into which warrants may be converted (in shares) | shares                     700,000     700,000        
Dr. Jan Hsiao                                    
Related Party Transaction [Line Items]                                    
Private placement agreement value of shares   2,000,000                                
Dr. Frost                                    
Related Party Transaction [Line Items]                                    
Private placement agreement value of shares   70,000,000                                
Frost Real Estate Holdings LLC                                    
Related Party Transaction [Line Items]                                    
Area of real estate property (in square feet) | ft²                                   29,500
Lease payments per month in first year                                   $ 81,000
Lease payments per month in third year                                   $ 86,000
Federal Trade Commission Filing Fees | Dr. Jan Hsiao                                    
Related Party Transaction [Line Items]                                    
Related party transaction amount     $ 125,000                              
Federal Trade Commission Filing Fees | Dr. Frost                                    
Related Party Transaction [Line Items]                                    
Related party transaction amount       $ 280,000                            
Shares Received Upon Closing of Xenetic Transaction [Member] | Director                                    
Related Party Transaction [Line Items]                                    
Shares received upon closing of transaction (in shares) | shares                     31,240     31,240        
Reimbursement of Travel Expense | Dr. Frost                                    
Related Party Transaction [Line Items]                                    
Reimbursement paid to related party for travel                     $ 0     $ 160,000        
Common Stock | Neovasc                                    
Related Party Transaction [Line Items]                                    
Equity method investment, additional investment in period (in shares) | shares               20,547                    
Common Stock | COCP                                    
Related Party Transaction [Line Items]                                    
Equity method investment, additional investment in period (in shares) | shares                 138,889                  
Xenetic | OPKO Transaction Shares | Affiliate                                    
Related Party Transaction [Line Items]                                    
Issuance of shares (in shares) | shares                                 164,062  
Museum of Science, Inc | Dr Frost and Mr Pfenniger                                    
Related Party Transaction [Line Items]                                    
Related party future contribution                   $ 1,000,000.0                
Related party future contribution term                   4 years                
Convertible Debt                                    
Related Party Transaction [Line Items]                                    
Interest rate on credit facility       4.50%                            
Convertible Debt | COCP                                    
Related Party Transaction [Line Items]                                    
Additional investment in equity method investment             $ 1,000,000.0                      
Convertible Debt | Common Stock | COCP                                    
Related Party Transaction [Line Items]                                    
Shares received after conversion (in shares) | shares         538,544                          
5% Convertible Notes | Convertible Debt                                    
Related Party Transaction [Line Items]                                    
Interest rate on credit facility             5.00%                      
Debt face amount             $ 55,000,000.0                      
Series A Warrant | Neovasc                                    
Related Party Transaction [Line Items]                                    
Number of shares into which warrants may be converted (in shares) | shares               20,547                    
Proceeds from warrant exercises                       $ 1,200,000            
Series B Warrant | Neovasc                                    
Related Party Transaction [Line Items]                                    
Number of shares into which warrants may be converted (in shares) | shares               20,547                    
Shares received upon exercise of warrant (in shares) | shares           10,690                        
Series C Warrant | Neovasc                                    
Related Party Transaction [Line Items]                                    
Number of shares into which warrants may be converted (in shares) | shares               8,221                    
Shares received upon exercise of warrant (in shares) | shares                       22,660            
Line of Credit | Unsecured Debt                                    
Related Party Transaction [Line Items]                                    
Credit line capacity   $ 60,000,000                                
Interest rate on credit facility   10.00%                                
Line of Credit | Unsecured Debt | Dr. Frost                                    
Related Party Transaction [Line Items]                                    
Repayments of lines of credit $ 28,800,000