Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.20.1
Related Party Transactions (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Feb. 25, 2020
USD ($)
Oct. 29, 2019
USD ($)
$ / shares
shares
Feb. 20, 2019
USD ($)
Nov. 08, 2018
USD ($)
$ / shares
shares
Nov. 30, 2019
USD ($)
shares
Mar. 31, 2019
USD ($)
Feb. 28, 2019
USD ($)
May 31, 2018
shares
Apr. 30, 2018
shares
Feb. 28, 2018
USD ($)
Nov. 30, 2017
USD ($)
shares
Apr. 30, 2017
USD ($)
shares
Nov. 30, 2016
USD ($)
Mar. 31, 2020
USD ($)
shares
Mar. 31, 2019
USD ($)
shares
Dec. 31, 2018
Aug. 01, 2019
USD ($)
ft²
Mar. 01, 2019
shares
Nov. 30, 2015
USD ($)
Related Party Transaction [Line Items]                                      
Credit line capacity                           $ 98,656,000          
Private placement agreement number of shares (in shares) | shares       26,500,000                              
Private placement agreement price per share (in dollars per share) | $ / shares       $ 3.49                              
Private placement agreement value of shares       $ 92,500,000                              
Repayments of lines of credit                           $ 188,009,000 $ 35,313,000        
Reverse stock split                               0.01      
Reimbursement paid to related party for travel                             37,000        
Pharmsynthez                                      
Related Party Transaction [Line Items]                                      
Equity method investment, ownership percentage                           9.00%          
Zebra                                      
Related Party Transaction [Line Items]                                      
Equity method investment, ownership percentage                           29.00%          
Stock ownership percentage                           29.00%          
Neovasc                                      
Related Party Transaction [Line Items]                                      
Equity method investment, ownership percentage                           3.00%          
Additional investment in equity method investment                     $ 3,000,000.0                
ChromaDex Corporation                                      
Related Party Transaction [Line Items]                                      
Ownership percentage                           0.10%          
MabVax                                      
Related Party Transaction [Line Items]                                      
Ownership percentage                           1.00%          
COCP                                      
Related Party Transaction [Line Items]                                      
Equity method investment, ownership percentage                           5.00%          
Additional investment in equity method investment                       $ 1,000,000.0              
Number of shares into which warrants may be converted (in shares) | shares                           33,000          
NIMS                                      
Related Party Transaction [Line Items]                                      
Ownership percentage                           1.00%          
Eloxx Pharmaceuticals                                      
Related Party Transaction [Line Items]                                      
Ownership percentage                           3.00%          
BioCardia, Inc.                                      
Related Party Transaction [Line Items]                                      
Equity method investment, ownership percentage                           3.00%          
Ownership percentage                           3.00%          
Number of shares into which warrants may be converted (in shares) | shares                           47,000          
InCellDx, Inc                                      
Related Party Transaction [Line Items]                                      
Equity method investment, ownership percentage                           29.00%          
Number of shares into which warrants may be converted (in shares) | shares                           700,000          
Dr. Jan Hsiao                                      
Related Party Transaction [Line Items]                                      
Private placement agreement value of shares       2,000,000                              
Dr. Frost                                      
Related Party Transaction [Line Items]                                      
Private placement agreement value of shares       70,000,000                              
Frost Real Estate Holdings LLC                                      
Related Party Transaction [Line Items]                                      
Area of real estate property (in square feet) | ft²                                 29,500    
Lease payments per month in first year                                 $ 89,000    
Lease payments per month in third year                                 $ 101,000    
Federal Trade Commission Filing Fees | Dr. Jan Hsiao                                      
Related Party Transaction [Line Items]                                      
Related party transaction amount           $ 125,000                          
Federal Trade Commission Filing Fees | Dr. Frost                                      
Related Party Transaction [Line Items]                                      
Related party transaction amount             $ 280,000                        
Shares Received Upon Closing of Xenetic Transaction | Director                                      
Related Party Transaction [Line Items]                                      
Shares received upon closing of transaction (in shares) | shares                           31,240          
Reimbursement of Travel Expense | Dr. Frost                                      
Related Party Transaction [Line Items]                                      
Reimbursement paid to related party for travel                           $ 94,000          
Common Stock | Neovasc                                      
Related Party Transaction [Line Items]                                      
Equity method investment, additional investment in period (in shares) | shares                     20,547                
Common Stock | COCP                                      
Related Party Transaction [Line Items]                                      
Equity method investment, additional investment in period (in shares) | shares                       138,889              
Xenetic | OPKO Transaction Shares | Affiliate                                      
Related Party Transaction [Line Items]                                      
Issuance of shares (in shares) | shares                                   164,062  
Museum of Science, Inc | Dr Frost and Mr Pfenniger                                      
Related Party Transaction [Line Items]                                      
Related party future contribution                         $ 1,000,000.0            
Related party future contribution term                         4 years            
Convertible Debt                                      
Related Party Transaction [Line Items]                                      
Interest rate on credit facility             4.50%                        
Convertible Debt | COCP                                      
Related Party Transaction [Line Items]                                      
Additional investment in equity method investment                   $ 1,000,000.0                  
Convertible Debt | Common Stock | COCP                                      
Related Party Transaction [Line Items]                                      
Shares received after conversion (in shares) | shares               538,544                      
5% Convertible Notes | Convertible Debt                                      
Related Party Transaction [Line Items]                                      
Interest rate on credit facility                   5.00%                  
Debt face amount                   $ 55,000,000.0                  
Series A Warrant | Neovasc                                      
Related Party Transaction [Line Items]                                      
Number of shares into which warrants may be converted (in shares) | shares                     20,547                
Proceeds from warrant exercises                             $ 1,200,000        
Series B Warrant | Neovasc                                      
Related Party Transaction [Line Items]                                      
Number of shares into which warrants may be converted (in shares) | shares                     20,547                
Shares received upon exercise of warrant (in shares) | shares                 10,690                    
Series C Warrant | Neovasc                                      
Related Party Transaction [Line Items]                                      
Number of shares into which warrants may be converted (in shares) | shares                     8,221                
Shares received upon exercise of warrant (in shares) | shares                             22,660        
Line of Credit | Unsecured Debt                                      
Related Party Transaction [Line Items]                                      
Credit line capacity $ 100,000,000     $ 60,000,000                              
Interest rate on credit facility 11.00%     10.00%                              
Line of Credit | Unsecured Debt | Dr. Frost                                      
Related Party Transaction [Line Items]                                      
Repayments of lines of credit     $ 28,800,000                                
Revolving Credit Facility | New Credit Agreement | Line of Credit                                      
Related Party Transaction [Line Items]                                      
Credit line capacity                                     $ 75,000,000.0
Commitment fee (as a percent) 0.25%                                    
IPO                                      
Related Party Transaction [Line Items]                                      
Common stock issued (in shares) | shares   50,000,000                                  
Common stock price (in dollars per share) | $ / shares   $ 1.50                                  
Net proceeds   $ 70,000,000                                  
Over-Allotment Option                                      
Related Party Transaction [Line Items]                                      
Common stock issued (in shares) | shares         4,227,749                            
Net proceeds         $ 6,000,000                            
Members of Senior Management | IPO                                      
Related Party Transaction [Line Items]                                      
Common stock issued (in shares) | shares   2,415,000