Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.21.1
Related Party Transactions (Details)
1 Months Ended 3 Months Ended
Feb. 25, 2020
USD ($)
Aug. 31, 2020
USD ($)
Nov. 30, 2016
USD ($)
Mar. 31, 2021
USD ($)
shares
Mar. 31, 2020
USD ($)
Aug. 01, 2019
USD ($)
ft²
Nov. 30, 2015
USD ($)
Related Party Transaction [Line Items]              
Credit line capacity       $ 105,795,000      
Reimbursement paid to related party for travel       0 $ 94,000    
Detect Genomix | Variable Interest Entity, Not Primary Beneficiary              
Related Party Transaction [Line Items]              
Additional investment in equity method investment       $ 245,000      
Equity method investment, ownership percentage       49.00%      
Pharmsynthez              
Related Party Transaction [Line Items]              
Equity method investment, ownership percentage       9.00%      
Zebra              
Related Party Transaction [Line Items]              
Stock ownership percentage       29.00%      
Zebra | Variable Interest Entity, Not Primary Beneficiary              
Related Party Transaction [Line Items]              
Equity method investment, ownership percentage       29.00%      
Neovasc              
Related Party Transaction [Line Items]              
Equity method investment, ownership percentage       1.00%      
ChromaDex Corporation              
Related Party Transaction [Line Items]              
Ownership percentage       0.10%      
MabVax              
Related Party Transaction [Line Items]              
Ownership percentage       1.00%      
COCP              
Related Party Transaction [Line Items]              
Equity method investment, ownership percentage       4.00%      
NIMS              
Related Party Transaction [Line Items]              
Ownership percentage       1.00%      
Eloxx Pharmaceuticals              
Related Party Transaction [Line Items]              
Ownership percentage       3.00%      
BioCardia, Inc.              
Related Party Transaction [Line Items]              
Equity method investment, ownership percentage       1.00%      
Ownership percentage       1.00%      
InCellDx, Inc              
Related Party Transaction [Line Items]              
Equity method investment, ownership percentage       29.00%      
Frost Real Estate Holdings LLC              
Related Party Transaction [Line Items]              
Area of real estate property (in square feet) | ft²           29,500  
Lease payments per month in first year           $ 89,000  
Lease payments per month in third year           $ 101,000  
Federal Trade Commission Filing Fees | Dr. Jan Hsiao              
Related Party Transaction [Line Items]              
Related party transaction amount   $ 125,000          
Federal Trade Commission Filing Fees | Dr. Frost              
Related Party Transaction [Line Items]              
Related party transaction amount   $ 280,000          
Shares Received Upon Closing of Xenetic Transaction | Director              
Related Party Transaction [Line Items]              
Shares received upon closing of transaction (in shares) | shares       31,240      
Mednax Services, Inc. | Detect Genomix | Variable Interest Entity, Not Primary Beneficiary              
Related Party Transaction [Line Items]              
Additional investment in equity method investment       $ 255,000      
Equity method investment, ownership percentage       51.00%      
Museum of Science, Inc | Dr Frost and Mr Pfenniger              
Related Party Transaction [Line Items]              
Related party future contribution     $ 1,000,000.0        
Related party future contribution term     4 years        
Line of Credit | Unsecured Debt              
Related Party Transaction [Line Items]              
Credit line capacity $ 100,000,000            
Interest rate on credit facility 11.00%            
Revolving Credit Facility | New Credit Agreement | Line of Credit              
Related Party Transaction [Line Items]              
Credit line capacity             $ 75,000,000.0
Commitment fee (as a percent) 0.25%