Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.8.0.1
Related Party Transactions (Details)
1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2017
USD ($)
shares
Aug. 31, 2017
shares
Jul. 31, 2017
USD ($)
shares
Jun. 30, 2017
shares
May 31, 2017
USD ($)
shares
Apr. 30, 2017
USD ($)
shares
Dec. 31, 2016
USD ($)
shares
Aug. 31, 2016
USD ($)
shares
Jan. 31, 2016
USD ($)
shares
Sep. 30, 2017
USD ($)
shares
Sep. 30, 2016
USD ($)
Sep. 30, 2017
USD ($)
shares
Sep. 30, 2016
USD ($)
Feb. 28, 2017
USD ($)
Jan. 01, 2017
USD ($)
ft²
Nov. 30, 2016
USD ($)
Oct. 31, 2016
shares
Zebra                                  
Related Party Transaction [Line Items]                                  
Stock ownership percentage                       29.00%          
Equity method investment, ownership percentage 29.00%                 29.00%   29.00%          
Sevion                                  
Related Party Transaction [Line Items]                                  
Equity method investment, ownership percentage 31.00%                 31.00%   31.00%          
Additional investment in equity method investment | $     $ 1,500,000                            
Equity method investment, additional investment in period (in shares)     10,000,000                            
Number of shares into which warrants may be converted (in shares) 300,000                 300,000   300,000          
Neovasc                                  
Related Party Transaction [Line Items]                                  
Equity method investment, ownership percentage 4.00%                 4.00%   4.00%          
Number of shares into which warrants may be converted (in shares) 1,000,000                 1,000,000   1,000,000          
ChromaDex Corporation                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, ownership percentage 1.00%                 1.00%   1.00%          
MabVax                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, ownership percentage 4.00%                 4.00%   4.00%          
Available-for-sale investment, additional investment in period | $     $ 100,000   $ 500,000     $ 1,000,000                  
Number of shares into which warrants may be converted (in shares) 200,000                 200,000   200,000          
COCP                                  
Related Party Transaction [Line Items]                                  
Equity method investment, ownership percentage 9.00%                 9.00%   9.00%          
Additional investment in equity method investment | $           $ 1,000,000   2,000,000                  
Number of shares into which warrants may be converted (in shares) 1,000,000                 1,000,000   1,000,000          
Eloxx Pharmaceuticals                                  
Related Party Transaction [Line Items]                                  
Ownership percentage, cost method                       3.00%          
Cost method investment | $ $ 1,500,000                 $ 1,500,000   $ 1,500,000          
ARNO                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, ownership percentage 5.00%                 5.00%   5.00%          
Available-for-sale investment, additional investment in period | $               $ 300,000 $ 300,000                
InCellDx, Inc                                  
Related Party Transaction [Line Items]                                  
Equity method investment, ownership percentage 28.00%                 28.00%   28.00%          
Number of shares into which warrants may be converted (in shares) 700,000                 700,000   700,000          
BioCardia, Inc.                                  
Related Party Transaction [Line Items]                                  
Equity method investment, ownership percentage 5.00%                 5.00%   5.00%          
Available-for-sale investment, ownership percentage 5.00%                 5.00%   5.00%          
Number of shares into which warrants may be converted (in shares) 5,000,000                 5,000,000   5,000,000          
NIMS                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, ownership percentage 1.00%                 1.00%   1.00%          
Frost Real Estate Holdings LLC                                  
Related Party Transaction [Line Items]                                  
Area of real estate property (in square feet) | ft²                             29,500    
Lease payments per month in first year | $                             $ 81,000    
Lease payments per month in third year | $                             $ 86,000    
Dr Frost                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, additional investment in period | $             $ 2,500,000                    
Sevion                                  
Related Party Transaction [Line Items]                                  
Debt face amount | $                           $ 300,000.0   $ 200,000.0  
Shares received in conversion of notes receivable (in shares)   4,100,000                              
Reimbursement Of Travel Expense | Dr Frost                                  
Related Party Transaction [Line Items]                                  
Reimbursement paid to related party for travel | $                   $ 168,000 $ 154,000 $ 309,000 $ 274,000        
Common Stock | MabVax                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, additional investment in period (in shares)               207,900                  
Number of shares into which warrants may be converted (in shares)               415,800                  
Common Stock | COCP                                  
Related Party Transaction [Line Items]                                  
Equity method investment, additional investment in period (in shares)           4,166,667   4,878,050                  
Common Stock | ARNO                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, additional investment in period (in shares)               714,285 714,285                
Number of shares into which warrants may be converted (in shares)               357,142                  
Common Stock | BioCardia, Inc.                                  
Related Party Transaction [Line Items]                                  
Investment owned (in shares)                                 5,027,726
Common Stock | Dr Frost                                  
Related Party Transaction [Line Items]                                  
Investment owned (in shares)             19,230,769                    
Common Stock | Sevion                                  
Related Party Transaction [Line Items]                                  
Shares received upon conversion (in shares) 1,250,006                                
Series G Preferred Stock | MabVax                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, additional investment in period (in shares)     152,143   285,714                        
Series I Preferred Stock | MabVax                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investment, additional investment in period (in shares)         322,820                        
Preferred C Stock | Eloxx Pharmaceuticals                                  
Related Party Transaction [Line Items]                                  
Cost method investment, shares purchased during period (in shares)       99,915                          
Preferred C Stock | Sevion                                  
Related Party Transaction [Line Items]                                  
Shares converted (in shares) 66,667                                
Museum of Science, Inc | Dr Frost and Mr Pfenniger                                  
Related Party Transaction [Line Items]                                  
Related party future contribution | $                               $ 1,000,000