Quarterly report pursuant to Section 13 or 15(d)

Related Party Transactions (Details)

v3.21.2
Related Party Transactions (Details)
1 Months Ended 3 Months Ended 6 Months Ended
Feb. 25, 2020
USD ($)
Aug. 31, 2020
USD ($)
Nov. 30, 2016
USD ($)
Jun. 30, 2021
USD ($)
shares
Jun. 30, 2020
USD ($)
Jun. 30, 2021
USD ($)
shares
Jun. 30, 2020
USD ($)
Dec. 31, 2020
USD ($)
Aug. 01, 2019
USD ($)
ft²
Nov. 30, 2015
USD ($)
Apr. 30, 2013
Related Party Transaction [Line Items]                      
Credit line capacity       $ 106,257,000   $ 106,257,000          
Amounts outstanding under line of credit       16,197,000   16,197,000   $ 22,954,000      
Reimbursement paid to related party for travel       $ 43,000 $ 0 $ 43,000 $ 94,000        
Detect Genomix | Variable Interest Entity, Not Primary Beneficiary                      
Related Party Transaction [Line Items]                      
Additional investment in equity method investment   $ 245,000                  
Equity method investment, ownership percentage   49.00%                  
Pharmsynthez                      
Related Party Transaction [Line Items]                      
Equity method investment, ownership percentage       9.00%   9.00%         9.00%
Zebra                      
Related Party Transaction [Line Items]                      
Stock ownership percentage           29.00%          
Zebra | Variable Interest Entity, Not Primary Beneficiary                      
Related Party Transaction [Line Items]                      
Equity method investment, ownership percentage       29.00%   29.00%          
Neovasc                      
Related Party Transaction [Line Items]                      
Equity method investment, ownership percentage       1.00%   1.00%          
ChromaDex Corporation                      
Related Party Transaction [Line Items]                      
Ownership percentage       0.10%   0.10%          
COCP                      
Related Party Transaction [Line Items]                      
Equity method investment, ownership percentage       3.00%   3.00%          
NIMS                      
Related Party Transaction [Line Items]                      
Ownership percentage       1.00%   1.00%          
Eloxx Pharmaceuticals                      
Related Party Transaction [Line Items]                      
Ownership percentage       2.00%   2.00%          
BioCardia, Inc.                      
Related Party Transaction [Line Items]                      
Equity method investment, ownership percentage       1.00%   1.00%          
Ownership percentage       1.00%   1.00%          
InCellDx, Inc                      
Related Party Transaction [Line Items]                      
Equity method investment, ownership percentage       29.00%   29.00%          
Frost Real Estate Holdings LLC                      
Related Party Transaction [Line Items]                      
Area of real estate property (in square feet) | ft²                 29,500    
Lease payments per month in first year                 $ 89,000    
Lease payments per month in fifth year                 $ 101,000    
Federal Trade Commission Filing Fees | Dr. Jan Hsiao                      
Related Party Transaction [Line Items]                      
Related party transaction amount   $ 125,000                  
Federal Trade Commission Filing Fees | Dr. Frost                      
Related Party Transaction [Line Items]                      
Related party transaction amount   280,000                  
Shares Received Upon Closing of Xenetic Transaction | Director                      
Related Party Transaction [Line Items]                      
Shares received upon closing of transaction (in shares) | shares       31,240   31,240          
Mednax Services, Inc. | Detect Genomix | Variable Interest Entity, Not Primary Beneficiary                      
Related Party Transaction [Line Items]                      
Additional investment in equity method investment   $ 255,000                  
Equity method investment, ownership percentage   51.00%                  
Museum of Science, Inc | Dr Frost and Mr Pfenniger                      
Related Party Transaction [Line Items]                      
Related party future contribution     $ 1,000,000.0                
Related party future contribution term     4 years                
Line of Credit | Unsecured Debt                      
Related Party Transaction [Line Items]                      
Credit line capacity $ 100,000,000                    
Amounts outstanding under line of credit       $ 0   $ 0          
Revolving Credit Facility | New Credit Agreement | Line of Credit                      
Related Party Transaction [Line Items]                      
Credit line capacity                   $ 75,000,000.0  
Commitment fee (as a percent) 0.25%