Annual report pursuant to Section 13 and 15(d)


12 Months Ended
Dec. 31, 2021
Feb. 25, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K/A    
Document Annual Report true    
Document Period End Date Dec. 31, 2021    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 001-33528    
Entity Registrant Name OPKO Health, Inc.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 75-2402409    
Entity Address, Address Line One 4400 Biscayne Blvd.    
Entity Address, City or Town Miami,    
Entity Address, State or Province FL    
Entity Address, Postal Zip Code 33137    
City Area Code (305)    
Local Phone Number 575-4100    
Title of 12(b) Security Common Stock, $.01 par value per share    
Trading Symbol OPK    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer Yes    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag true    
Entity Shell Company false    
Entity Public Float     $ 1,607,181,353
Entity Common Stock, Shares Outstanding   681,525,181  
Documents Incorporated by Reference None.    
Amendment Description OPKO Health, Inc. (the “Company,” “we,” “us,” or “our”) is filing this Amendment No. 1 on Form 10-K/A (this “Amendment No. 1” or “Form 10-K/A”) to amend our Annual Report on Form 10-K for the fiscal year ended December 31, 2021, originally filed with the Securities and Exchange Commission (“SEC”) on March 1, 2022 (the “Original Filing”), to include the information required by statement Items 10 through 14 of Part III of Form 10-K. The information was previously omitted from the Original Filing in reliance on General Instruction G(3) to Form 10-K, which permits the information in the above-referenced items to be incorporated in the Form 10-K by reference to our definitive proxy statement if such statement is filed no later than 120 days after our fiscal year-end. We are filing this Amendment No. 1 to include the information required in Part III of Form 10-K because a definitive proxy statement containing such information will not be filed by us within 120 days after the end of the fiscal year covered by the Form 10-K. The reference on the cover of the Original Form 10-K to the incorporation by reference to portions of our definitive proxy statement into Part III of the Original Form 10-K is hereby deletedIn accordance with Rules 12b-15 and 13a-14 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), we have also amended Part IV, Item 15 to include currently dated certifications pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 from our principal executive officer and principal financial and accounting officer. Because no financial statements have been included in this Amendment No. 1 and this Amendment No. 1 does not contain or amend any disclosure with respect to Items 307 and 308 of Regulation S-K, paragraphs 3, 4 and 5 of the certifications have been omitted. Similarly, because no financial statements have been included in this Amendment No. 1, certifications pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 have been omitted.Except as described above, this Amendment No. 1 does not amend any other information set forth in the riginal Filing, and we have not updated disclosures included therein to reflect any subsequent events. This Amendment No. 1 should be read in conjunction with the Original Form 10-K and with our other filings made with the SEC subsequent to the filing of the Original Form 10-K.    
Entity Central Index Key 0000944809    
Amendment Flag true    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY