Annual report pursuant to Section 13 and 15(d)


12 Months Ended
Dec. 31, 2021
Feb. 25, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Dec. 31, 2021    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 001-33528    
Entity Registrant Name OPKO Health, Inc.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 75-2402409    
Entity Address, Address Line One 4400 Biscayne Blvd.    
Entity Address, City or Town Miami,    
Entity Address, State or Province FL    
Entity Address, Postal Zip Code 33137    
City Area Code (305)    
Local Phone Number 575-4100    
Title of 12(b) Security Common Stock, $.01 par value per share    
Trading Symbol OPK    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer Yes    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag true    
Entity Shell Company false    
Entity Public Float     $ 1,607,181,353
Entity Common Stock, Shares Outstanding   681,455,306  
Documents Incorporated by Reference Portions of the registrant’s definitive proxy statement for its 2022 Annual Meeting of Stockholders are incorporated by reference in Items 10, 11, 12, 13, and 14 of Part III of this Annual Report on Form 10-K.    
Entity Central Index Key 0000944809    
Amendment Flag false    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY