Annual report pursuant to Section 13 and 15(d)

Related Party Transactions - Textual (Details)

v3.3.1.900
Related Party Transactions - Textual (Details)
$ / shares in Units, ft² in Thousands
1 Months Ended 12 Months Ended
Jan. 16, 2014
$ / shares
shares
Jan. 16, 2014
USD ($)
$ / shares
shares
Nov. 30, 2015
USD ($)
shares
Oct. 31, 2015
USD ($)
$ / shares
shares
Jul. 31, 2015
USD ($)
shares
Feb. 28, 2014
USD ($)
Oct. 31, 2013
USD ($)
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
$ / shares
Dec. 31, 2013
USD ($)
$ / shares
Dec. 31, 2012
USD ($)
Aug. 31, 2015
$ / shares
May. 31, 2015
$ / shares
May. 28, 2015
USD ($)
ft²
Aug. 31, 2013
Jan. 31, 2013
USD ($)
Jan. 30, 2013
USD ($)
2033 Senior Notes | Notes Due February 1, 2033                                  
Related Party Transaction [Line Items]                                  
Stock price | $ / shares               $ 10.05 $ 9.99 $ 8.44              
Debt face amount                                 $ 175,000,000.0
Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Stock price | $ / shares                       $ 12.38 $ 13.88        
Zebra                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage               29.00%                  
Zebra | Series A-2 Preferred Stock                                  
Related Party Transaction [Line Items]                                  
Investment owned, shares | shares     420,000                            
Sevion                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage               3.00%                  
Warrants to purchase common shares | shares         333,333     500,000                  
Sevion | Series C Preferred Stock                                  
Related Party Transaction [Line Items]                                  
Investment owned, shares | shares         66,667                        
Sevion | Common stock investments, available for sale                                  
Related Party Transaction [Line Items]                                  
Investment owned, shares | shares         666,667                        
Neovasc                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage               4.00%                  
Warrants to purchase common shares | shares               1,000,000                  
Chromadex Corporation                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investments, ownership percentage               2.00%                  
MabVax                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investments, ownership percentage               1.00%                  
Investment owned, shares | shares       340,909                          
Warrants to purchase common shares | shares       170,454       1,800,000                  
Stock price | $ / shares       $ 1.10                          
Invested in common shares       $ 375,000                          
ARNO                                  
Related Party Transaction [Line Items]                                  
Available-for-sale investments, ownership percentage               4.00%                  
Warrants to purchase common shares | shares               800,000                  
Biozone                                  
Related Party Transaction [Line Items]                                  
Invested in common shares                     $ 1,700,000            
Cocrystal Pharma                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage               8.00%                  
Dr Frost | PROLOR                                  
Related Party Transaction [Line Items]                                  
Beneficially owned held by members                             5.00%    
Equity Method Investee | Cocrystal Pharma                                  
Related Party Transaction [Line Items]                                  
Private placement financing   $ 2,750,000                              
Investment owned, shares | shares 1,000,000 1,000,000                              
Warrants to purchase common shares | shares 1,000,000 1,000,000                              
Invested in common shares   $ 500,000                              
Warrants duration 10 years                                
Warrants exercisable price (in USD per share) | $ / shares $ 0.50 $ 0.50                              
Dr. Hsiao and Mr. Rubin | PROLOR                                  
Related Party Transaction [Line Items]                                  
Beneficially owned held by members                             5.00%    
Frost Gamma Investments Trust and Hsu Gamma Investment, L.P. | 2033 Senior Notes | Notes Due February 1, 2033                                  
Related Party Transaction [Line Items]                                  
Debt face amount                               $ 175,000,000  
Teva | FineTech                                  
Related Party Transaction [Line Items]                                  
Sale of API to TEVA               $ 0 $ 300,000 $ 300,000              
Real Estate Holdings LLC                                  
Related Party Transaction [Line Items]                                  
Area of real estate property (in square feet) | ft²                           25      
Monthly operating lease payment in year one                           $ 66,000      
Monthly operating lease payment in year five                           75,000      
Tenant improvements for rent reduction                           $ 216,000      
FTC Filings | Dr Frost                                  
Related Party Transaction [Line Items]                                  
Payments for filing fees           $ 280,000                      
FTC Filings | Dr. Hsiao                                  
Related Party Transaction [Line Items]                                  
Payments for filing fees             $ 170,000                    
Equity Method Investee | Zebra                                  
Related Party Transaction [Line Items]                                  
Invested in common shares     $ 1,000,000                            
Equity Method Investee | Sevion                                  
Related Party Transaction [Line Items]                                  
Private placement financing         $ 500,000                        
Reimbursement Of Travel Expense | Dr Frost                                  
Related Party Transaction [Line Items]                                  
Reimbursement paid to related party for travel               $ 595,000 $ 175,000 $ 93,000              
InCellDx, Inc                                  
Related Party Transaction [Line Items]                                  
Investment ownership percentage               27.00%